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ORIGINAL RESEARCH article

Front. Public Health

Sec. Infectious Diseases: Epidemiology and Prevention

Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1598269

Scaling up tuberculosis case finding via private providers in Ghana: an impact evaluation using interrupted time series

Provisionally accepted
Kenneth  Mawuta HayiborKenneth Mawuta Hayibor1,2*Gloria Ivy  MensahGloria Ivy Mensah2Ernest  KenuErnest Kenu3Dziedzorm  AwalimeDziedzorm Awalime4Jabina  AnamanJabina Anaman4Adwoa  Asante-PokuAdwoa Asante-Poku2Olena  IvanovaOlena Ivanova5Abhishek  BakuliAbhishek Bakuli5Andrea  RachowAndrea Rachow5,6,7Nortey  Nii Hanson-NorteyNortey Nii Hanson-Nortey4
  • 1CIH LMU Center for International Health, Ludwig Maximilians University, Munich, Bavaria, Germany
  • 2Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana
  • 3School of Public Health, College of Health Sciences, University of Ghana, Legon, Greater Accra, Ghana
  • 4Aurum Institute Ghana, Accra, Ghana
  • 5Division of Infectious Diseases and Tropical Medicine, CIHLMU Center for International Health, LMU Munich University Hospital, Munich, Bavaria, Germany
  • 6German Centre for Infection Research (DZIF), Partner Site Munich,, Munich, Germany
  • 7Unit of Global Health, Helmholtz Zentrum München, German Research Centre for Environmental Health (HMGU),, Neuherberg, Germany

The final, formatted version of the article will be published soon.

Background: Although TB services are free in Ghana, TB case detection remains low and mostly limited to public facilities. To address this, a Public-Private Mix (PPM) Directly Observed Therapy (DOT) model was introduced, involving community private healthcare providers and the National Health Insurance Scheme (NHIS) to boost TB case detection rates. Methods: This impact evaluation focuses on four key interventions targeting vulnerable populations in Ghana's two largest metropolitan areas between the last quarter of 2018 and the first quarter of 2020. Screening and TB register data were collected from implementing facilities, along with TB case notifications from 2015 to 2022 for both intervention and control areas. Comparative interrupted time series (ITS) analysis was used to evaluate the effect of the interventions on quarterly TB case notifications. Results: During the intervention period, a total of 563,868 persons were screened for TB, 12,121 of these were presumptive for TB and 590 persons were diagnosed with TB. Of the diagnosed TB cases, 95.3% (562) were bacteriologically confirmed. The overall TB screening yield was 104.6 cases per 100,000 population. In the intervention area, TB case notifications increased from 1392 cases in 2018 to 1462 cases in 2019 while they decreased from 853 to 778 in the control area. The ITS analyses detected positive post-intervention trend differences in all forms of TB and bacteriologically confirmed TB notification case rates between the intervention and control areas. Conclusion: Expanding free TB services through a PPM DOT model and sustained community engagement can increase TB case detection in urban areas. National TB programs should adopt and scale this approach to enhance TB surveillance and control.

Keywords: Private healthcare providers, Public-private mix, Tuberculosis, Active case notification, Community Engagement

Received: 22 Mar 2025; Accepted: 04 Aug 2025.

Copyright: © 2025 Hayibor, Mensah, Kenu, Awalime, Anaman, Asante-Poku, Ivanova, Bakuli, Rachow and Hanson-Nortey. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Kenneth Mawuta Hayibor, CIH LMU Center for International Health, Ludwig Maximilians University, Munich, Bavaria, Germany

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