ORIGINAL RESEARCH article
Front. Public Health
Sec. Health Economics
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1598497
This article is part of the Research TopicIntegrating Economics into Population Health: Assessing Policies and OutcomesView all 7 articles
Impact of Social Factors and Health Campaigns on the Burden of Idiopathic Epilepsy: Inequality, decomposition, generalized and synthetic difference-in-differences study
Provisionally accepted
Xuewen Rong1,2
Dongting Yu1,2Wei Zhao1,3Jingyu Xiao1,2Du Feng1,2Gengfeng Chen1,2Zemeng Cao1,2
Liming Shu1,4*- 1Guangzhou Medical University, Guangzhou, China
- 2Nanshan College, Guangzhou Medical University, Guangzhou, China
- 3Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong Province, China
- 4The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China
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AbstractBackgroundIdiopathic epilepsy is a major global health burden that causes premature death and disability. Previous studies have systematically analysed trends in the burden of idiopathic epilepsy. However, analyses of the impact of social factors, health campaigns and policies on the burden of idiopathic epilepsy are lacking. This study aims to fill that gap.MethodsWe used data from the 2021 Global Burden of Disease (GBD) and calculated the estimated annual percentage changes (EAPC) to assess trends. Decomposition analysis breaks down changes in the burden of idiopathic epilepsy into three factors. Correlation analysis measures the association between the EAPC and social development. Inequality analysis illustrates the disparity in the burden of idiopathic epilepsy among countries. Generalized difference-in-differences (GDID) and synthetic difference-in-differences (SDID) analyses are used to quantify the impact of health campaigns or policies on the burden of idiopathic epilepsy.ResultsWith respect to incidence, ageing had a negative impact. The correlation between the sociodemographic index (SDI) and EAPC had a rho value of -0.18. The slope index of inequality for the mortality burden decreased from 1.97 to 1.62. After the policy shock, the age-standardized rate (ASR) of years lived with disability (YLD) in the Caribbean increased significantly to 4.59 (95% CI: 0.96 to 8.22), while the all-age YLD rate in the U.S. increased (5.18, 95% CI: 0.66 to 9.70) for both sexes.ConclusionThis study explores the impact of social factors and health campaigns on the burden of idiopathic epilepsy. We emphasize the need for targeted prevention and treatment strategies to effectively address the burden of idiopathic epilepsy.
Keywords: idiopathic epilepsy, Disability-adjusted life years, Generalized difference-in-differences, Synthetic Difference-in-Differences, Inequality, Global burden of disease
Received: 23 Mar 2025; Accepted: 15 May 2025.
Copyright: © 2025 Rong, Yu, Zhao, Xiao, Feng, Chen, Cao and Shu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Liming Shu, Guangzhou Medical University, Guangzhou, China
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