ORIGINAL RESEARCH article

Front. Public Health

Sec. Public Mental Health

Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1599602

This article is part of the Research TopicYouth Mental Health, Particularly in Asian PopulationsView all 74 articles

Global, regional and national burden of depressive disorders in adolescents and young adults, 1990-2021: systematic analysis of the Global Burden of Disease Study 2021

Provisionally accepted
Le  ZhaoLe Zhao1,2Yan  LouYan Lou1,2Yuexian  TaoYuexian Tao2*Hangsai  WanngHangsai Wanng2,3Nan  XuNan Xu2,4
  • 1University of Malaya, Kuala Lumpur, Malaysia
  • 2Hangzhou Normal University, Hangzhou, Zhejiang Province, China
  • 3Jinhua Polytechnic, Jinhua, Zhejiang Province, China
  • 4Quzhou University, Quzhou, China

The final, formatted version of the article will be published soon.

Background: To promote evidence-based policymaking, this research attempts to investigate global trends in depressive disorders among individuals aged 15-39 from 1990 to 2021, determine risk factors, and forecast the next trends from 2022 to 2050.Methods: Data from the Global Burden of Disease (GBD) 2021 database were analyzed to look at the global, national, and regional burden of depressive disorders among individuals aged 15-39 from 1990 to 2021. Incidence rates, disability-adjusted life years (DALYs), and contributions of various risk factors to DALYs were also examined in this research. All incidence and disability-adjusted life year (DALY) rates were calculated per 100,000 population and are presented with corresponding 95% uncertainty intervals (UIs). The burden of disease through 2050 was projected using Bayesian age-period-cohort (BAPC) modeling.

Keywords: depressive disorders, Global burden of disease, Incidence, Disability-adjusted life years, Risk factors

Received: 25 Mar 2025; Accepted: 13 May 2025.

Copyright: © 2025 Zhao, Lou, Tao, Wanng and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Yuexian Tao, Hangzhou Normal University, Hangzhou, Zhejiang Province, China

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