BRIEF RESEARCH REPORT article
Front. Public Health
Sec. Public Mental Health
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1603623
This article is part of the Research TopicCOVID and Psychotropics 2024: Lessons Learnt and Future Directions for ResearchView all 5 articles
The Association between COVID-19 Lockdown and Disease Severity, Quality of Life, and Mental Health in Patients with Psoriasis: A Cross-Sectional Study in Southwestern China
Provisionally accepted
- 1First Affiliated Hospital of Chongqing Medical University, Chongqing, China
- 2University of Toledo, Toledo, Ohio, United States
- 3College of Medicine, Central Michigan University, Mt. Pleasant, Michigan, United States
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Background: Our study aimed to clarify the impact of home quarantine on disease severity, quality of life, and mental health in psoriasis patients through the multidimensional analysis of the status of home quarantine, the severity of psoriasis, quality of life, and depression scores during the COVID-19 pandemic. Methods: From 2022 to 2023, we conducted telephone follow-up on 963 psoriasis patients. Participants' demographic characteristics, psoriasis condition, home quarantine duration, quality of life and depression symptom scores were collected. The association between COVID-19 lockdown and patient-reported outcomes were investigated with pearson correlation and Spearman correlation. Results: A total of 963 participants were recruited, finally 605 were enrolled. The mean values of age and disease duration was 43.63 years, 12.35 years, 67.6% were male. Patients with disease-related impaired quality of life (DLQI > 5) accounted for 7.44%. 65 patients had varying degrees of depression symptoms (QIDS-SR16 > 5 points). The result of correlation analysis revealed a positive correlation between BSA and both DLQI and QIDS-SR16 scores (R=0.27, P < 0.001; R = 0.08, P < 0.05). Conclusions: Our results revealed that COVID-19 lockdown had a measurable impact on disease severity, quality of life, and mental health in psoriasis patients. Many individuals experienced varying degrees of symptoms aggravation during the lockdown. The severity of psoriasis was negatively correlated with quality of life and positively correlated with depression symptoms, with elderly patients being particularly vulnerable to depression. These findings highlight the importance for dermatologists to integrate mental health assessment and support into routine psoriasis management.
Keywords: COVID-191, Psoriasis2, Disease severity3, quality of life4, mental health5, Cross-sectional study6
Received: 06 Apr 2025; Accepted: 07 Oct 2025.
Copyright: © 2025 Shao, He, Chen, Kapur, Cruz and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ping Wang, wang_ping@hospital.cqmu.edu.cn
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