ORIGINAL RESEARCH article
Front. Public Health
Sec. Aging and Public Health
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1606719
Burden of Heart Failure Attributable to Chronic Kidney Disease in Older Adults (1990-2021): An Analysis from the Global Burden of Disease Study
Provisionally accepted
- 1Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong Province, China
- 2Guangdong Provincial People's Hospital, Guangzhou, Guangdong Province, China
- 3Southern Medical University, Guangzhou, Guangdong, China
- 4The Second Affiliated Hospital, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: Heart failure (HF) is a critical global health issue, with chronic kidney disease (CKD) as a significant contributing factor. Both primarily affect older adults, with prevalence rising substantially after age 60. This study examined global trends and disparities in CKD-associated HF among older adults from 1990 to 2021.Methods: Utilizing data from the Global Burden of Disease (GBD) 2021, the study analyzed the prevalence and years lived with disability (YLDs) of CKD-associated HF. Joinpoint regression assessed trends from 1990 to 2021 globally, regionally, and nationally. Health inequity analysis, including the slope index of inequality and health inequality concentration index, evaluated disparities across countries.Results: From 1990 to 2021, the prevalence and YLDs of CKD-associated HF increased globally, with an average annual percentage change (AAPC) of 2.21% (95% confidence interval [CI], 2.17-2.25) and 2.20% (95% CI, 2.16-2.24), respectively. Males exhibited higher prevalence and YLDs but demonstrated a slower increase than females. The low-SDI region exhibited the highest burden, while the high-SDI region showed an unfavorable increase. Socioeconomic disparities were decreased but persisted. From 1990 to 2021, the inequality slope index for prevalence decreased from 143.66 (95% CI, 167.68-119.65) to 114.12 (95% CI, 151.59-76.65), whereas the health inequality concentration index improved from -0.21 (95% CI, -0.30 to -0.12) to -0.07 (95% CI, -0.14 to 0) for prevalence.Conclusions: The global burden of CKD-associated HF has increased substantially, with persistent disparities across gender and SDI levels. Strengthening preventive measures and implementing effective interventions are essential to addressing this escalating health challenge.
Keywords: Heart Failure, Chronic Kidney Disease, disease burden, Trends, health inequalities
Received: 07 Apr 2025; Accepted: 31 May 2025.
Copyright: © 2025 Liu, Huang, Shen, Xu, Gu and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhaoyu Lu, The Second Affiliated Hospital, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510000, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.