ORIGINAL RESEARCH article
Front. Public Health
Sec. Environmental Health and Exposome
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1608861
This article is part of the Research TopicAssessing Environmental Influences on Maternal and Infant Health Amidst Climate ChangeView all 3 articles
Association between endocrine disrupting chemicals and female infertility: a study based on NHANES database
Provisionally accepted
- Hunan Provincial People's Hospital, Changsha, China
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Background: Controversy persists regarding the impact of endocrine disrupting chemicals (EDCs) on female infertility, and the specific EDCs that cause female infertility remain unclear. This study aims to examine the associations between various EDCs metabolites and female infertility using data from the female population in the National Health and Nutrition Examination Survey (NHANES) conducted betweenMethods: A cross-sectional study on reproductive-age women aged 18-45 years was conducted, with data retrieved from the NHANES database. Multivariate logistic regression analysis was performed to evaluate the association between EDCs metabolites and female infertility. Subgroup analysis was applied to stratify by age and body mass index (BMI). Results were summarized using an odds ratio (OR) with a 95% confidence interval (CI).Results: A total of 3,982 women were enrolled, comprising 463 infertile women and 3,519 control women. The results showed that increased exposure to EDCs metabolites (including DnBP, DEHP, DiNP, DEHTP, PAEs, Equol, PFOA, and PFUA) was significantly associated with female infertility, with odds ratios of 2.10 (95% CI:
Keywords: endocrine disrupting chemicals, PAEs, Equol, PFASs, Female infertility, NHANES
Received: 09 Apr 2025; Accepted: 22 May 2025.
Copyright: © 2025 Hailun, Ting, Bingru, Zhe, Wen and Qianling. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhu Hailun, Hunan Provincial People's Hospital, Changsha, China
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