ORIGINAL RESEARCH article
Front. Public Health
Sec. Aging and Public Health
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1610661
This article is part of the Research TopicThe Future of Cancer Surveillance ResearchView all 29 articles
Global Burden of Skin Cancer and its Subtypes: A Comprehensive Analysis from 1990 to 2021 with Projections to 2040
Provisionally accepted
- Guangzhou University of Chinese Medicine, Guangzhou, China
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Background: Skin cancer represents a significant global public health concern. Comprehensive analysis of its global burden provides critical insights for evidence-based interventions. This study systematically evaluates the global disease burden of skin cancer and its subtypes. Methods: This study analyzed GBD 2021 data to assess ASIR and ASDR trends for total skin cancer and its subtypes (1990-2021), stratified by geography, age, and sex, using APC modeling, decomposition analysis, and inequality assessments, with projections through 2040. Results: First, skin cancer ASIR increased from 1990 to 2021, while ASDR significantly decreased. Second, geographical heterogeneity existed in distribution of histological subtypes. Third, skin cancer burden demonstrated age-dependent progression with compositional variance in subtypes across age groups. Fourth, sex disparities intensified beyond age 55, with increasing longitudinal divergence. Fifth, ASIR positively correlated with SDI, while ASDR showed a non-linear relationship characterized by initial increase followed by reduction. Sixth, international disparities in skin cancer burden demonstrated a decreasing trend. Finally, projections to 2040 indicate a continued increase in ASIR, accompanied by a persistent decline in ASDR. Conclusion: ASIRs of total skin cancer and its subtypes showed increasing trends, while ASDRs demonstrated decreasing patterns, with significant heterogeneity across regions, age groups, and sex.
Keywords: Global burden of disease, Skin Cancer, Melanoma, Squamous cell carcinoma, Basal cell carcimoma, prediction
Received: 12 Apr 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Chen and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaoyi Liu, Guangzhou University of Chinese Medicine, Guangzhou, China
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