BRIEF RESEARCH REPORT article
Front. Public Health
Sec. Aging and Public Health
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1612512
This article is part of the Research TopicInnovative Personalized Medicine Strategies for Managing Multi-MorbidityView all 10 articles
Health-Related Quality of Life among multimorbid patients using the EQ-5D-5L value set for India
Provisionally accepted
Krushna Chandra Sahoo1,2
Abhinav Sinha1*
Girish Chandra Dash1
Rakesh Kumar Sahoo1
DEBDUTTA BHATTACHARYA1
Purna Chandra Dash3Lalatendu Mohanty4
Pranab Mahapatra4Kavitha Rajsekhar2Sanghamitra Pati1*- 1Regional Medical Research Center (ICMR), Bhubaneswar, India
- 2Department of Health Research, Ministry of Health and Family Welfare, New Delhi, Delhi, India
- 3SCB Medical College and Hospital, Cuttack, Odisha, India
- 4Kalinga Institute of Medical Sciences (KIMS), Bhubaneswar, Odisha, India
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Multimorbidity presents major challenges to healthcare systems worldwide. Assessing health-related quality-of-life (HRQoL) in multimorbid patients is essential for understanding the overall impact of the patient's health conditions on well-being and the complexities of patient management. This study assessed the HRQoL of multimorbid patients in India using the EQ-5D-5L value set. This observational study included 906 patients from tertiary healthcare facilities in Odisha, India, and used consecutive time-based sampling methods, conducted from January to April 2023. The study examined the relationship between HRQoL measures and utility scores using ordinary least squares regression and multiple regression analysis. The results showed that mean utility scores decreased as the number of health conditions increased, with scores of 0.677 for one condition, 0.577 for two conditions, 0.354 for three conditions, and 0.098 for four or more conditions. Combining stroke/paralysis with other health issues resulted in negative utility ratings. The findings showed that younger age (p=0.003), urban residence (p=0.027), higher education (p=0.018), being married (P=0.006), engaging in physical activity (p=0.001), and having fewer health conditions were independently associated with higher utility scores. The study highlights the correlation between multimorbidity and HRQoL in older adults, highlighting implications for healthcare systems and clinical and policy decisions for multimorbid patients.
Keywords: health-related quality of life, multimorbidity, EQ-5D-5L, utility score, HTA
Received: 16 Apr 2025; Accepted: 28 Aug 2025.
Copyright: © 2025 Sahoo, Sinha, Dash, Sahoo, BHATTACHARYA, Dash, Mohanty, Mahapatra, Rajsekhar and Pati. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Abhinav Sinha, Regional Medical Research Center (ICMR), Bhubaneswar, India
Sanghamitra Pati, Regional Medical Research Center (ICMR), Bhubaneswar, India
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