ORIGINAL RESEARCH article
Front. Public Health
Sec. Children and Health
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1618334
Analysis of the Global Burden of Neonatal Disorders and Risk Factors from 1990 to 2021 : Findings from the Global Burden of Disease Study
Provisionally accepted
- 1Hangzhou Normal University, Hangzhou, China
- 2Engineering Research Center of Mobile Health Management System, Ministry of Education, Hangzhou Normal University, Hangzhou, Jiangsu Province, China
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Background : Neonatal health represents a critical global issue, encapsulating both the advancements and challenges faced by health systems at both global and national levels. Neonatal disorders not only impose a significant disease burden, diminishing the quality of life for affected individuals, but they also contribute to substantial economic strain. Methods : This article utilizes the Global Burden of Disease 2021 database to describe the global burden of neonatal disorders in 2021 through age-standardized incidence rate , age-standardized prevalence rate , age-standardized death rate , and age-standardized disability-adjusted life years rate. Additionally, it employs the estimated annual percentage change to delineate the trends in the global burden of neonatal disorders from 1990 to 2021. Results : The global age-standardized incidence rate, age-standardized prevalence rate , age-standardized death rate , and age-standardized disability-adjusted life years rate for neonatal disorders were 437.43 (95% UI = 433.20 to 441.95) per 100,000 population, 437.43 ( 433.20 to 441.95), 29.57 ( 25.37 to 34.26) , and 2941.98 (2547.76 to 3384.20), respectively. Conclusion : From 1990 to 2021, the global burden of neonatal disorders exhibited a general downward trend, with a particularly pronounced burden in South Asia and Southern Sub-Saharan Africa. Countries characterized by low socio-demographic index and low-middle socio-demographic index faced a disproportionately higher burden of neonatal disorders. Low birth weight emerged as a significant contributor to both the age-standardized death rate and the age-standardized disability-adjusted life years rate associated with global neonatal disorders. Therefore, health departments across various nations should prioritize the enhancement of healthcare systems and the quality of care to alleviate the burden of neonatal disorders.
Keywords: Neonatal disorders, disease burden, GBD, Prevalence, death, Disability-adjusted life years
Received: 25 Apr 2025; Accepted: 08 Oct 2025.
Copyright: © 2025 Wang, Xiong, Yang, Wang, Yu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Huilin Wang, 3220368503@qq.com
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