ORIGINAL RESEARCH article
Front. Public Health
Sec. Injury Prevention and Control
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1618928
Optimal L-Arginine Dosage for Pressure Injury Healing in Home Care Settings: A Six-Month Retrospective Analysis
Provisionally accepted
- 1Chi Mei Medical Center, Tainan, Taiwan
- 2Section Nursing Science, Rotterdam, Netherlands
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Background: Pressure injuries present a significant challenge for patients receiving home care, particularly those with limited mobility. Although L-arginine supplementation has shown promise for wound healing, the optimal dosage remains unclear. This study compared the effectiveness of two daily L-arginine doses (7 g versus 14 g) in treating pressure injuries over a six-month period. Methods: We retrospectively reviewed the medical records of 120 adult patients with grade 3 or 4 pressure injuries who received home care between June and December 2023. Patient wounds were evaluated using the DESIGN-R assessment tool, which measures various aspects of wound healing. Statistical analysis was performed using SPSS 26.0, employing generalized estimating equations (GEE) to account for repeated measurements over time. Results: The study found that patients receiving the 7 g daily L-arginine dose showed significantly better wound healing after one month compared to those receiving 14 g (p < .001). While healing rates varied throughout the study period, the 7 g dose consistently demonstrated superior outcomes by the six-month mark (p < .05). Notably, the higher 14 g dose did not provide additional healing benefits at any point during the study. Conclusion: Our findings indicate that a daily 7 g L-arginine supplement effectively promotes both early-and late-stage healing of pressure injuries in home-care patients. This lower dose not only matches or exceeds the healing outcomes of the higher dose, but also presents a more cost-effective treatment option. Healthcare providers may consider implementing a 7 g dosage as a standard protocol for pressure injury treatment in home care settings.
Keywords: pressure injuries, L-arginine supplementation, Wound Healing, home care, Nutritional intervention, Retrospective study
Received: 09 Jun 2025; Accepted: 20 Aug 2025.
Copyright: © 2025 Chen, Pu, Huang, Lin, Hung and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yu-Yu Li, Chi Mei Medical Center, Tainan, Taiwan
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