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ORIGINAL RESEARCH article

Front. Public Health

Sec. Infectious Diseases: Epidemiology and Prevention

Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1623627

Prevalence and genotype assessment of HPV in 73,697 females from Beijing, China

Provisionally accepted
Mingjian BaiMingjian Bai1Yunxiang LiYunxiang Li2Fucun MaFucun Ma1Qian GaoQian Gao1Zhiyong LvZhiyong Lv1Yueming XuYueming Xu3Jing FengJing Feng1Fengxian FuFengxian Fu1Guowei LiangGuowei Liang1*
  • 1Aerospace Center Hospital, Beijing, China
  • 2Peking University Fifth School of Clinical Medicine, Beijing, China
  • 3University of Wisconsin-Madison, Wisconsin-Madison, United States

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Background: The present study aimed to assess the prevalence and genotype distribution of Human papillomavirus (HPV) in Beijing females. Methods: A total of 73,697 subjects (both Department of Gynecology (n = 35666) and Physical Examination center (n = 38031)) were retrieved between June 2014 and December 2023. HPV testing was performed by Tellgenplex® HPV-27 DNA genotyping Test system. Results: An overall HPV infection rate of 17.28% (12,736/73,697) over the past decade (2014 to 2023), with a significant decrease in annual incidence (p < 0.001).HPV-52, 16, and 58 were predominant in high-risk types, while HPV-61, 81, and 43 were the most prevalent in low-risk HPV types. Age-specific patterns revealed bimodal infection peaks in individuals under 21 and between 51 ~ 56 years. Furthermore, a significant increase in HPV infection rates was observed with the progression of pathological severity (p < 0.001). Conclusions: This study emphasizes the importance of HPV infection rate from real word and developing vaccines specifically for the Chinese population. In the future, it is necessary to design more suitable vaccines based

Keywords: Human papillomavirus, Prevalence, Genotype, Pathology, Vaccination

Received: 08 May 2025; Accepted: 20 Aug 2025.

Copyright: © 2025 Bai, Li, Ma, Gao, Lv, Xu, Feng, Fu and Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Guowei Liang, Aerospace Center Hospital, Beijing, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material