ORIGINAL RESEARCH article
Front. Public Health
Sec. Injury Prevention and Control
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1632773
The Burden of Neurological Diseases in G7 Countries from 1990 to 2021 and Projections for the Next 30 Years: A Global Burden of Disease Study Author information
Provisionally accepted
- 1900 Hospital of the Joint Logistics Team of the Chinese PLA, Fuzhou, China
- 2Fujian Medical University, Fuzhou, China
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Background: Neurological disorders have become a significant global public health challenge due to their high rates of disability and mortality. This study analyzed epidemiological trends of neurological disorders in G7 countries from 1990 to 2021 based on Global Burden of Disease (GBD) 2021 data and predicted the disease burden for the next 30 years.Using the Joinpoint regression model and the Nordpred Age-Period-Cohort (APC) model, the study evaluated indicators such as incidence, mortality, and Disability-Adjusted Life Years (DALYs) of neurological disorders. It also analyzed the impact of gender, age, and social factors on the disease burden.The overall burden of neurological disorders in G7 countries is lower than the global level, but there are significant gender differences. Women have a higher prevalence rate, which may be related to migraine and hormonal fluctuations, while men have more prominent Years of Life Lost (YLL) due to premature death, except in Japan and Italy. Regarding age distribution, the risk of disease gradually increases for individuals over 10 years old, and the mortality rate rises sharply after 70 years old. The association between aging and neurodegenerative diseases (such as Alzheimer's disease) is particularly significant. Historical trend analysis from 1990 to 2021 shows that the global age-standardized incidence and mortality rates have remained stable overall. However, male mortality rates have increased significantly in the United States, Japan, and Germany. Predictions for the next 30 years indicate that despite stabilizing age-standardized rates, the number of neurological disease cases in G7 countries will continue to increase due to population growth and aging.The study untangles the unique challenges faced by G7 countries in preventing and controlling neurological disorders. It emphasizes the need to develop precise intervention strategies that consider age, gender, and social factors, providing valuable insights for developing countries.
Keywords: Neurological Diseases, Burden, G7 countries, Epidemiological trend analysis, projection
Received: 21 May 2025; Accepted: 21 Oct 2025.
Copyright: © 2025 Ji, Lin, Chen, Jiang, Wang, Cui and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaoping Cui, cui_xping@163.com
Kuihua Wang, kuihuawang@fjmu.edu.cn
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