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ORIGINAL RESEARCH article

Front. Public Health

Sec. Infectious Diseases: Epidemiology and Prevention

Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1635476

This article is part of the Research TopicExploring SARS-CoV-2 Interactions in Aging and Comorbid PopulationsView all 4 articles

Predictors of mortality among critically ill SARS-CoV-2 infected patients-A Retrospective cohort study, Kerala, India

Provisionally accepted
Anil SathyadasAnil Sathyadas1Aravind ReghukumarAravind Reghukumar1Thekkumkara Surendran AnishThekkumkara Surendran Anish2*Gnanaseelan Kanakamma LibuGnanaseelan Kanakamma Libu1Kiran Vishnu NarayanKiran Vishnu Narayan1Prajitha K CPrajitha K C3Anisha SharahudeenAnisha Sharahudeen1Dhanusha ChandranDhanusha Chandran1Muralidharan Rohini AthiraraniMuralidharan Rohini Athirarani4L SindhuL Sindhu4Parackalparambil Sukumaran SonaParackalparambil Sukumaran Sona4TP SreekanthTP Sreekanth1Chintha SujathaChintha Sujatha1Thomas IypeThomas Iype5Suresh Muthezhathu KesavadasSuresh Muthezhathu Kesavadas1Kavitha RaviKavitha Ravi1A NizarudeenA Nizarudeen1Parameswaran N HariParameswaran N Hari6K RajamohananK Rajamohanan7Thomas MathewThomas Mathew1John PanickerJohn Panicker8MKC NairMKC Nair8
  • 1Government Medical College, Thiruvananthapuram, Thiruvananthapuram, India
  • 2Kerala One Health Centre for Nipah Research and Resilience, Kozhikode, India
  • 3Government Medical College Thiruvananthapuram, Thiruvananthapuram, India
  • 4Government College of Nursing, Thiruvananthapuram, India
  • 5Director of Medical Education, Thiruvananthapuram, India
  • 6Medical College of Wisconsin, Milwaukee, United States
  • 7School of Public Health, Thiruvananthapuram, India
  • 8Dr MRS Menon Foundation, Thiruvananthapuram, India

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Background: Preventing the in-hospital mortality of critically ill patient is the last opportunity to saves lives during a pandemic. It was a need for the hospital settings of global south to further prioritize the individuals in this vulnerable group to allocate scares resources because of large numbers of such patients admitted in hospitals during pandemics. We, in this study flag the risk factors for in-hospital mortality for critically ill patients at the time of a pandemic like COVID-Methods: This retrospective cohort study aimed to analyse the in-hospital mortality rate and predictors of mortality of patients with critically ill SARS-CoV-2 infection admitted to a Level 3 multi-disciplinary intensive care unit in India from15 th September 2020 to 31 st March 2021. We compared the incidence proportion of in-hospital mortality in different subgroups. We calculated the relative risk (RR) of clinical and biochemical factors under study for mortality outcome. We used principal component analysis to identify risky groups because the mortality predictors were found to have highly correlated one another in univariable analyses.Of the 431 adult study participants with a median (IQR) age of 48 (34-60) years, 26.2% (n=113) were aged 60 years or above, and 58.9 % (n= 254) were men. Significant predictors of mortality in patients with severe SARS-CoV-2 infection were; age more than 60 years [

Keywords: Critically ill COVID-19, COVID-19 mortality, Mortality predictors, Kerala, India

Received: 26 May 2025; Accepted: 28 Jul 2025.

Copyright: © 2025 Sathyadas, Reghukumar, Anish, Libu, Narayan, K C, Sharahudeen, Chandran, Athirarani, Sindhu, Sona, Sreekanth, Sujatha, Iype, Kesavadas, Ravi, Nizarudeen, Hari, Rajamohanan, Mathew, Panicker and Nair. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Thekkumkara Surendran Anish, Kerala One Health Centre for Nipah Research and Resilience, Kozhikode, India

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