ORIGINAL RESEARCH article
Front. Public Health
Sec. Health Economics
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1647634
This article is part of the Research TopicEconomic Burdens and Efficiency in Cancer CareView all articles
Global Respiratory Tumour Mortality Correlation Study with Economic Level, 2000-2019
Provisionally accepted
Mingjie Wang1
Zhiyuan Chen2*- 1Qilu Hospital of Shandong University, Jinan, China
- 2Shandong Provincial Hospital, Jinan, China
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Objective: To investigate the relationship between global tracheobronchial lung cancer mortality rates and economic levels, and to assess the associated regional economic burden. Understanding these associations is crucial for global health resource allocation, informing cancer prevention and control strategies, and providing data to support lung cancer and economic policy development worldwide. Methods: We analyzed respiratory cancer mortality data (ICD-10 codes C33-C34) from the WHO Mortality Database (2000-2019). Age-standardized mortality rates (ASMRs) were calculated to describe spatiotemporal distribution characteristics. Non-parametric comparisons (Wilcoxon ranksum test) assessed sex differences in mortality. Partial Spearman rank correlation analysis evaluated the association between national income level (World Bank classification) and disease mortality. Results: The core cohort comprised 50 countries with sufficient data. The global mean ASMR for respiratory cancers showed a decreasing trend from 2000 to 2019. Countries within the Global Respiratory Tumour Mortality Registry System (GRTMRS) were predominantly high-income (68%) and European (52%). A significant positive correlation was observed between income level and respiratory cancer mortality (Spearman's ρ = 0.422, P<0.001). ASMRs were consistently and significantly higher among males than females (Wilcoxon rank-sum test, P<0.001). Conclusion: Between 2000 and 2019, tracheobronchial lung cancer mortality globally may be positively correlated with national economic level, particularly in high-and middle-income countries. Agestandardized mortality rates are significantly higher in males than females. Paradoxically, these findings suggest that increasing economic development may coincide with elevated respiratory cancer mortality, emphasizing the critical need for balanced prevention strategies tailored to both high-and low-income settings.
Keywords: Respiratory Tumour, Mortality rate, economic, Gender difference, formulation
Received: 16 Jun 2025; Accepted: 28 Jul 2025.
Copyright: © 2025 Wang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhiyuan Chen, Shandong Provincial Hospital, Jinan, China
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