ORIGINAL RESEARCH article
Front. Public Health
Sec. Injury Prevention and Control
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1659091
Global, regional, and national burden of spinal cord lesion at neck level a systematic analysis of incidence, prevalence, YLDs with projections to 2046
Provisionally accepted
- 1Guangxi Medical University, Nanning, China
- 2The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: Spinal cord lesion at neck level imposes significant global morbidity, yet cervical-specific burden analysis remains limited.Using Global Burden of Disease (GBD) 2021 data , we analyzed incidence, prevalence, and years lived with disability (YLDs) across 204 countries/territories, stratified by sex, age, socio-demographic index (SDI) regions, GBD super regions, and countries. Age-period-cohort (APC) model and Bayesian age-period-cohort (BAPC) model projected trends to 2046. Results: In 2021, global incidence was 306,568 (age-standardized incidence rate [ASIR] 3.78/100,000), prevalence 7.42 million (age-standardized prevalence rate [ASPR] 88.47/100,000), and YLDs 2.91 million (age-standardized YLDs rate[ASYLDR] 34.72/100,000). Males had higher burdens than females, with cases peaking at 45-64 years. Middle-SDI regions had the highest absolute cases (79,611 incidence), while high-SDI regions showed the highest age-standardized rates (ASRs) (ASIR 5.86/100,000). From 1990-2021, absolute cases rose, but ASRs declined.Projections predict rising absolute cases through 2046.This study reveals marked regional and demographic disparities in cervical spinal cord lesion burden. Targeted prevention and healthcare planning in high-burden regions are essential to address this global health challenge.
Keywords: spinal cord lesion at neck level, global, disease burden, GBD, 2021
Received: 03 Jul 2025; Accepted: 14 Aug 2025.
Copyright: © 2025 Zhang, Zhao, Peng, Yang and Zong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shaohui Zong, Guangxi Medical University, Nanning, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.