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STUDY PROTOCOL article

Front. Public Health

Sec. Substance Use Disorders and Behavioral Addictions

Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1664492

This article is part of the Research TopicSubstance Use Research and Population HealthView all 7 articles

Integrating Qualitative Insights with Large Secondary Data: A Protocol for a Community-Engaged Mixed-Methods Study on Adolescent Substance Use

Provisionally accepted
Kazi Priyanka  SilmiKazi Priyanka Silmi1Paris  B Adkins-JacksonParis B Adkins-Jackson2""  University of California San Diego, Center for Com"" University of California San Diego, Center for Com3Carlos  Cardenas-IniguezCarlos Cardenas-Iniguez4Erika  A PughErika A Pugh1Yailene  PerexYailene Perex3Nayeli  C CervantesNayeli C Cervantes3Precious  PetersPrecious Peters1Stephanie  HammondsStephanie Hammonds1Igdalia  CovarrubiasIgdalia Covarrubias1""  Comit́e Organizador Latino de City Heights (COLCH)"" Comit́e Organizador Latino de City Heights (COLCH)5Jovita  MurilloJovita Murillo6Marybel  R GonzalezMarybel R Gonzalez1*
  • 1Department of Psychiatry and Behavioral Health, College of Medicine, The Ohio State University, Columbus, United States
  • 2Columbia University, New York, United States
  • 3University of California San Diego, La Jolla, United States
  • 4University of Southern California, Los Angeles, United States
  • 5Comit́e Organizador Latino de City Heights (COLCH), San Diego, California, United States
  • 6University of Louisville, Louisville, United States

The final, formatted version of the article will be published soon.

Understanding the factors of risk and resilience for youth substance use requires interdisciplinary and multi-level methodological approaches that integrate the community of study into the research process. This protocol describes a novel, community-engaged, modified convergent mixed-methods design to investigate factors of neighborhood social risk and resilience (NSRR) in relation to substance use and neurocognition among Hispanic adolescents living in neighborhoods with unequal opportunities and restricted access to resources. We propose a design for integrating primary qualitative data with secondary data from the Adolescent Brain Cognitive Development (ABCD) Study, the largest longitudinal adolescent cohort in the United States. Guided by community-engaged research practices, and socio-ecological and health disparities frameworks, the protocol centers on the experience of young adolescents. Our design prioritizes partnerships among academic, community, and grassroots organizations to co-develop study design conceptualization, recruitment and analysis plan, along with the interpretation and dissemination of results. The secondary quantitative data analysis leverages advanced statistical modeling to examine relationships between neighborhood level factors and substance use, providing measurable insights both at the population level and at the neighborhood level. Qualitative interviews with adolescents provide an opportunity for collecting a rich, community-grounded perspective that captures the lived experience of adolescents in how neighborhood factors shape adolescent health behaviors. Findings will be integrated using data integration and shared through academic, community-facing, and policy channels. This protocol highlights the importance of a community-engaged mixed-methods design that strengthens the cultural relevance, actionability, and validity of adolescent substance use research by embedding community voices throughout all phases of the research process.

Keywords: Community-engaged research, mixed-methods design, Secondary data, adolescentsubstance use, Qualitative

Received: 12 Jul 2025; Accepted: 02 Sep 2025.

Copyright: © 2025 Silmi, Adkins-Jackson, University of California San Diego, Center for Com, Cardenas-Iniguez, Pugh, Perex, Cervantes, Peters, Hammonds, Covarrubias, Comit́e Organizador Latino de City Heights (COLCH), Murillo and Gonzalez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Marybel R Gonzalez, Department of Psychiatry and Behavioral Health, College of Medicine, The Ohio State University, Columbus, United States

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