PERSPECTIVE article
Front. Public Health
Sec. Infectious Diseases: Epidemiology and Prevention
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1671769
This article is part of the Research TopicLeveraging Real-Time Genomic Surveillance to Combat Infectious Diseases and Antimicrobial ResistanceView all 12 articles
From structured surveys to outbreak investigations: advancing genomic surveillance of carbapenem-resistant Enterobacterales within the European Antimicrobial Resistance Genes Surveillance Network
Provisionally accepted
Anke Kohlenberg*
Marius LinkeviciusErik AlmEmmanuel RobesynOlov SvartströmDaniel PalmDominique Monnet
Diamantis Plachouras
Barbara Albiger- European Centre for Disease Prevention and Control, Solna, Sweden
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The European Antimicrobial Resistance Genes Surveillance Network (EURGen-Net) was established in 2017 to support the European survey of carbapenem-and/or colistin-resistant Enterobacterales in 37 countries. In parallel to large-scale international structured surveys with a central whole genome sequencing (WGS), EURGen-Net rapidly developed an approach for faster and more flexible investigations of cross-border outbreaks and emerging antimicrobial resistance of international concern in Europe, based on voluntary sharing of national WGS and epidemiological data for joint analysis. Here, we describe the approach and methodology, practical experience with implementation, benefits and challenges of the current model for genomic surveillance of carbapenem-resistant Enterobacterales at the European level.
Keywords: carbapenem-resistant Enterobacterales, surveillance, whole genome sequencing, cross-border spread, antimicrobial resistance
Received: 23 Jul 2025; Accepted: 13 Oct 2025.
Copyright: © 2025 Kohlenberg, Linkevicius, Alm, Robesyn, Svartström, Palm, Monnet, Plachouras and Albiger. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Anke Kohlenberg, anke.kohlenberg@ecdc.europa.eu
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