SYSTEMATIC REVIEW article
Front. Public Health
Sec. Aging and Public Health
This article is part of the Research TopicEnhancing Oral Health Literacy and Quality of Life: Strategies for a Healthier FutureView all 7 articles
Systematic review and meta-analysis of oral frailty prevalence among older hospitalized patients.
Provisionally accepted
- Department of Neurosurgery, Second Affiliated Hospital of Soochow University, Suzhou, China
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Abstract Background: Oral frailty, characterized by reduced oral function, represents a significant yet understudied issue among hospitalized patients, affecting treatment outcomes. Objective: To determine the prevalence of oral frailty in hospitalized patients and identify high-risk groups through stratified analyses. Methods: Nine databases, including PubMed, Web of Science, Embase, Cochrane Library, CINAHL, CNKI, Sinomed, and Wanfang, were systematically searched from their inception to July 2025. Data analysis was conducted using Stata 15.0 software, employing a random-effects model to estimate overall prevalence. Subgroup analysis and meta-regression were performed to identify sources of heterogeneity. Results: This meta-analysis included 27 studies involving 11,575 hospitalized patients. The overall prevalence of oral frailty was found to be 51% (95% CI: 47%- 55%). Among different disease groups, patients with cancer had the highest prevalence (62%, 95% CI: 57%-66%), while patients with renal disease had the lowest (39%, 95% CI: 32%-47%). Regional analysis indicated a prevalence of 52% (95% CI: 48%-56%) among patients in mainland China, and 45% (95% CI: 37%-53%) in other regions. Cross-sectional studies reported a prevalence of 52% (95% CI: 48%- 57%), whereas cohort studies reported 42% (95% CI: 36%-48%). Disease type accounted for substantial heterogeneity (I²=94.35%). No publication bias was detected. Conclusions: The findings suggest that oral frailty is highly prevalent among hospitalized patients, with prevalence varying by disease type. Therefore, establishing specific screening programs for oral frailty and integrating professional oral care into routine medical treatment are recommended to mitigate the risk of complications.
Keywords: Hospitalized patients, Oral frailty, Prevalence, Systematic review, Meta-analysis
Received: 07 Aug 2025; Accepted: 26 Nov 2025.
Copyright: © 2025 Gong, Tan, Yan, Qian and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yusu Li
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