Incidence and Persistent Infection Rates of Type-specific HPV Among HIV-Infected Male in China: A Five-Year retrospective study

SIwei Zhang¹Huan Liu²Zhiyan Huang³Siyu Duan¹Yuting Zhang²Yanjing Li⁴Wenzhu Chu¹Yan Wang⁴Rongqing Yang^1*Lanlan Wei^1*

• ¹Shenzhen Third People's Hospital, Shenzhen, China
• ²First Affiliated Hospital of Harbin Medical University, Harbin, China
• ³Guangzhou Medical University, Guangzhou, China
• ⁴Harbin Medical University, Harbin, China

Although the 9-valent HPV vaccine (9v-HPV) has been approved for males in China, it has received limited public attention. This study aimed to explore the incidence and persistence of different HPV types in HIV-related males and emphasize the importance of vaccination. Herein, 758 male patients with multiple HPV detection( ≥3) from 2018 to 2023 in our hospital were enrolled for statistical analysis, including 113 Men who have Sex with Men (MSM) patients. HIV and HPV infection statuses were confirmed respectively by ELISA, PCR, WB and nucleic acid kit. Statistical analysis revealed that the incidence of 9v-HPV-covered high-risk(HR) HPV infections were 68.1% (HIV+ total males), 43.2% (HIV-total males), 67.6% (HIV+ MSM) and 42.2% (HIV-MSM). HPV persistence was significantly prolonged in HIV+ patients than HIV-cases (P < 0.001). Markov model demonstrated that HIV increased incidence risks of HPV52, 58, 45, 35, 39, 51, 59, 68, 66, 73, 82, 81 and reduced the clearance rates of HPV16 ,18, 6, 11, 58, 33, 31, 56 in males. These findings highlight the increased burden of HPV infection among HIV+ individuals. Timely vaccination will benefit males by preventing HPV infection and consequently reducing the associated disease burden.