ORIGINAL RESEARCH article
Front. Public Health
Sec. Infectious Diseases: Epidemiology and Prevention
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1698578
People living with HIV coinfected with HBV at the Nkembo Outpatient Treatment Center, Gabon : Prevalence and associated factors
Provisionally accepted
Christian Mangala1*
Rolf Moukanda-Ifoundou1,2Rachyda Massolou-Outata2Christian Mombo-Maganga1,3Gwladys Esmeralda Matsomo-Kombet1,3Josiane Alda Boukandou-Bina1Darly Yenze-Mouelé3Alain Moutsinga1,3Serge Christian Okolongo-Mayani1,4Denis Maulot-Bangola1Hervé Ouambo1Joseph Fokam1,5Brice Ongali6,7Guy Joseph Lemamy7- 1Catholic University of Central Africa, Yaoundé, Cameroon
- 2Outpatient Treatment Center of Nkembo, Libreville, Gabon
- 3National Public Health Laboratory, Libreville, Gabon
- 4Medical Peyrie Center, Libreville, Gabon
- 5Chantal Biya International Reference Center, Yaoundé, Cameroon
- 6International Institute for Biomedical Research and Biotechnology Carles Kambangoye, Libreville, Gabon
- 7University of Health Sciences, Libreville, Gabon
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Background : Hepatitis B virus (HBV) is a major public health problem worldwide that affects many people, including people living with HIV (PLHIV). In Gabon, HBV infection remains a concern among PLHIV. This study aimed to determine the prevalence of HBV and risk factors among PLHIV in Nkembo Outpatient Treatment Center of Gabon. Methods : This study was cross-sectional and conducted at Nkembo Outpatient Treatment Center in Gabon, from March 25 to May 31, 2024 among 410 PLHIV. A blood sample (plasma) was taken. The OneSite HBV-5 Rapid test was used for the detection of HBs antigen and HBe antigen. CD4+ counting was performed on BD FACSPrestoTM Systems. The measurement of HBV and HIV viral load was carried out on the QuantStudioTM5 device after performing an extraction using the GenoXtract® version 1.0. Statistical analysis of the data was done using SPSS software version 21.0. Results : Out of 410 PLHIV, the seroprevalence of HBV was 10.5% (95% CI: 7.9-13.8). Alcohol intake (aOR=2.1, 95% CI :1.2-3.4, P=0.006), elevated transaminases (aOR=3.1, 95% CI :1.8-4.8, P=0.0001), CD4+ count less than 200 cells/mm3 (aOR=3.6, 95% CI : 2.2-5.8, P=0.0001) and HIV viral load greater than 1000 copies/mL (aOR=2.5, 95% CI : 1.4-4.4, P=0.001) and unvaccinated (aOR=2.2 95% CI :1.2-3.8 P=0.011) were risk factors associated with HBV infection in PLHIV. Conclusion : The prevalence of HBV remain a concern among PLHIV. HBV screening is strongly recommended to improve the management of PLHIV in order to reduce this burden of co-infection.
Keywords: Hepatitis B virus, People living with HIV, Prevalence, Risk factors, Gabon
Received: 03 Sep 2025; Accepted: 16 Oct 2025.
Copyright: © 2025 Mangala, Moukanda-Ifoundou, Massolou-Outata, Mombo-Maganga, Matsomo-Kombet, Boukandou-Bina, Yenze-Mouelé, Moutsinga, Okolongo-Mayani, Maulot-Bangola, Ouambo, Fokam, Ongali and Lemamy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Christian Mangala, imohu2004@yahoo.fr
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