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ORIGINAL RESEARCH article

Front. Public Health

Sec. Infectious Diseases: Epidemiology and Prevention

This article is part of the Research TopicMathematical Modelling and Data Analysis in Infectious DiseasesView all 13 articles

Infectious Disease Prediction Model Based on Optimized Deep Learning Algorithm

Provisionally accepted
YongChao  JinYongChao Jin1,2*Qian  CaoQian Cao2Junling  ZhengJunling Zheng3Yunyue  LiuYunyue Liu4
  • 1School of Public Health, North China University of Science and Technology, Tangshan 063210, China, TANGSHAN CITY, HEBEI PROVINCE, China
  • 2College of Science, North China University of Science and Technology, TANGSHAN CITY, HEBEI PROVINCE, China
  • 3School of Mathematics and Information Technology, Hebei Normal University of Science & Technology, Qinhuangdao, China
  • 4Senior Department of Obstetrics and Gynecology, Chinese PLA Hospital, BEIJING, China

The final, formatted version of the article will be published soon.

Since the end of 2019, a novel coronavirus known as COVID-19 has caused a severe outbreak worldwide. Due to the complexity of epidemic data, traditional algorithms have struggled to accurately predict the development of the pandemic. The Autoregressive Integrated Moving Average (ARIMA) model is capable of capturing time-based trends in epidemic data, including seasonality, cyclic patterns, and long-term trends, which helps improve the accuracy of forecasting future epidemic trajectories. The Bidirectional Long Short-Term Memory (BiLSTM) network, a variant of the Recurrent Neural Network (RNN), is highly effective in handling sequential data. In epidemic data analysis, BiLSTM models can be applied to forecast future trends or conduct time series predictions. BiLSTM is able to capture temporal relationships and sequential patterns within data, thereby providing more accurate predictions. Genetic Algorithms (GA), inspired by biological evolution through operations such as selection, crossover, and mutation, offer an efficient approach to identifying the best-fit models and parameter configurations. By using GA, we can iteratively optimize epidemic forecasting models and enhance their performance over time. In this study, we proposed a hybrid model called GA-BiLSTM-ARIMA. Using COVID-19 case data from Japan, we calculated the GA-BiLSTM-ARIMA model's evaluation metrics: RMSE, MAE, MAPE, and R², which were 2262.42, 1672.07, 6.81, and 0.9764, respectively. The results demonstrate that the hybrid model outperforms both the standalone BiLSTM and ARIMA models in predictive performance. The GA-BiLSTM-ARIMA model successfully integrates the strengths of different models through a systematic and intelligently optimized hybrid strategy. When forecasting infectious disease time series data, this model achieves higher and more robust predictive accuracy compared to traditional single models or partial hybrid models. This type of analysis supports the development of more effective prevention and control strategies and delivers accurate information and early warnings to the public and policymakers, contributing to a better global response to pandemic challenges.

Keywords: ARIMA, BiLSTM, COVID-19, GA, GA-BiLSTM-ARIMA

Received: 11 Sep 2025; Accepted: 08 Dec 2025.

Copyright: © 2025 Jin, Cao, Zheng and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: YongChao Jin

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