CASE REPORT article
Front. Toxicol.
Sec. Clinical Toxicology
Volume 7 - 2025 | doi: 10.3389/ftox.2025.1557995
This article is part of the Research TopicMagnetic Resonance Imaging Contrast Agents: The Safety of GadoliniumView all 5 articles
Evaluating Toxic Encephalopathy from Occupational 1,2-Dichloroethane Exposure: Magnetic Resonance Imaging Contributions
Provisionally accepted
- 1Qilu Hospital, Shandong University, Jinan, China
- 2Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
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Background: 1,2-Dichloroethane is a commonly used industrial solvent. Acute or subacute occupational exposure can cause toxic encephalopathy; however, long-term changes in brain imaging are not frequently documented. Case presentation: A 39-year-old woman developed dizziness and forgetfulness nine days after performing glue coating. Her symptoms improved significantly after a seven-day break from work. However, after resuming work for three days, she returned with dizziness, headache, and anxiety. Brain magnetic resonance imaging (MRI) showed extensive edema and diffuse abnormal signal intensities in the cerebellar dentate nucleus, basal ganglia, and bilateral cerebral white matter. She was treated with salvianolate injection, magnesium isoglycyrrhizinate, and neurotrophic therapy. Two weeks after admission, her symptoms improved significantly, except for DCE-induced_toxic_encephalopathy 2 mild uncoordinated walking. The range of abnormal MRI signals remained consistent with previous findings. She was discharged the following day. She experienced worsened headache three days later.Computed tomography revealed diffuse cerebral edema. Despite treatment with mannitol, her headache rapidly worsened and was accompanied by nausea, vomiting, hypertension, bradycardia, and dyspnea, ultimately leading to unconsciousness. Follow-up MRI showed findings similar to the previous scan, except that the apparent diffusion coefficient (ADC) sequence had changed from hypointense to hyperintense. Shortly after the MRI examination, she experienced respiratory arrest.Unfortunately, she died 32 days after her initial admission due to severe cerebral injury and infection.Conclusions: Occupational exposure to 1,2-dichloroethane can lead to toxic encephalopathy, presenting as diffuse progressive cerebral edema. This case shows that brain imaging findings may not always correlate with the patient's clinical condition, so careful monitoring is essential.
Keywords: 1,2-Dichloroethane, Toxic encephalopathy, Occupational Exposure, cerebral edema, Magnetic Resonance Imaging, Clinical features
Received: 09 Jan 2025; Accepted: 09 Jun 2025.
Copyright: © 2025 Jian, Yu, Kan, Wang, Li and Jian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Guangcai Yu, Qilu Hospital, Shandong University, Jinan, China
Xiang Dong Jian, Qilu Hospital, Shandong University, Jinan, China
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