Frontiers in Toxicology

Original Research

Published on 13 May 2026

Next-generation full-thickness human skin models produced using 3D electrospun scaffolds and animal-component-free culture media

in In Vitro Toxicology

Patrick J. Hayden
Jayashree Chakravarty
Rayan K. Hodroj
Sar R. Lindner
Lisa M. Fitzgerald
Jacob T. Le Do
Hsin Tzu Keng
Vivek Patel
Holger P. Behrsing
Matthew D. Phaneuf

Frontiers in Toxicology

doi 10.3389/ftox.2026.1639389

319 views

Original Research

Published on 12 May 2026

Botulinum toxin type E alleviates trigeminal neuropathic pain via modulation of the HIF-1α–NLRP3 pathway

in Neurotoxicology

JoYoung Son
YuMi Kim
JinSook Ju
JaeYoung Kim
JeongSun Nam
YoonKyoung Cha
DongKuk Ahn

Frontiers in Toxicology

doi 10.3389/ftox.2026.1823460

365 views

Review

Published on 12 May 2026

Challenges and solutions in transitioning to animal-free standards: a comprehensive analysis of components in human cell-based developmental neurotoxicity assays

in In Vitro Toxicology

Julia Vanessa Spänle
Lisa Maria Haiber
Bettina Seeger

Frontiers in Toxicology

doi 10.3389/ftox.2026.1800157

454 views

Original Research

Published on 11 May 2026

PFOA/PFOS induce ferroptosis in bladder epithelial cells through inhibition of ACSL4 ubiquitination

in Environmental Toxicology

Hao Xu
Zhihua Ye
Juan Liu
Mengwei Liu
Qinghua Hu
Yi Liu
Qiankun Zhang
Jian Ou
Xin Shen
Xiaogang Chen

Frontiers in Toxicology

doi 10.3389/ftox.2026.1774625

351 views

Original Research

Published on 08 May 2026

Machine learning-integrated network toxicology uncovers glioma targets of DEHP

in Environmental Toxicology

Ren Li
Chaomin Ren
Lu He
Shule Wang
Geng Guo

Frontiers in Toxicology

doi 10.3389/ftox.2026.1771011

537 views

Original Research

Accepted on 07 May 2026

Molecular mechanisms of DEHP-associated neuroblastoma: an integrated network toxicology and molecular experimental investigation

in Neurotoxicology

Jingru Huang
Suwen Li
Lijian Cao
Siyi Yang
Shan Wang

Frontiers in Toxicology

110 views

Perspective

Accepted on 07 May 2026

Foodborne Illness Outbreaks Attributed to Chemical Hazards in the United States, 2011-2025

in Food and Nutritional Toxicology

Brett Weed
Lauren V Yeung
Omari Bandele
Cary Chen Parker

Frontiers in Toxicology

172 views

Original Research

Accepted on 06 May 2026

Impact of Liquid Dosing and Associated Cell 'Drowning' in a 3D Human Bronchial Epithelial Model used for Protease Exposure Studies

in In Vitro Toxicology

Georgina Hopkins
David Sheffield
Hugh Barlow
Anja Lalljie
Stella Cochrane
Lucy C Fairclough

Frontiers in Toxicology

110 views

Case Report

Accepted on 04 May 2026

Irreversible Dialysis-dependent Acute Tubular Necrosis caused by standard-dose of Carboplatin: a case report

in Clinical Toxicology

Chun-lin Fu
Andrew Chou
Tung-Ying Chen
Ming-Tso Yan

Frontiers in Toxicology

107 views

Case Report

Accepted on 04 May 2026

Hyperbaric Oxygen Therapy for Ischemic Encephalopathy Following Occupational Exposure to High-Concentration Toxic Gases: Two Case Reports

in Clinical Toxicology

Yang Pang
Jiaojiao Yuan
Xu Yuan
Xiaomin Chai
Si Li

Frontiers in Toxicology

171 views

Original Research

Accepted on 04 May 2026

Evaluation and Investigation of the Cardiotoxicity of the Potential Anti-Cholangiocarcinoma Drug Lanatoside C

in Clinical Toxicology

Yu-Hai Ma
Chong-Fei Huang
Hai-Dong Ma
Jin-Yu Zhao
Wen-An Wang
Zi-He Dong
Yi Shao
Long Gao
Jian-Jun Chen
Wenbo Meng

Frontiers in Toxicology

105 views

Original Research

Accepted on 04 May 2026

Toxicological Impacts of Environmentally Equivalent Microplastics and Cadmium Co-exposure in Tropical Freshwater Crab Sartoriana spinigera

in Environmental Toxicology

Ananya Chakraborty
Upayan Anam
Tanmoy Gupta
Md. Khalid Saifullah
Gourab Chowdhury
Md. Selim Reza
Mohammad Moniruzzaman
Petra Schneider
Mohammed Mahbub Iqbal
Mohammad Amzad Hossain

Frontiers in Toxicology

187 views

Policy and Practice Reviews

Published on 04 May 2026

Bridging gaps between scientific research and regulatory decision-making in Europe: roles of academia, risk assessors, and policymakers

in Regulatory Toxicology

Ana Fernandez-Agudo
Hannah Lester
Jose V. Tarazona
Fernando Rivero-Pino

Frontiers in Toxicology

doi 10.3389/ftox.2026.1829326

630 views

Original Research

Published on 04 May 2026

Visual–acoustic thigmotaxis in zebrafish larvae: a high throughput NAM for neurotoxicity assessment

in Neurotoxicology

Monica Torres-Ruiz
Maria Muñoz-Palencia
Antonio De la Vieja
Ana I. Cañas-Portilla

Frontiers in Toxicology

doi 10.3389/ftox.2026.1753174

456 views

Review

Published on 01 May 2026

Next generation validation for next generation risk assessment

in Regulatory Toxicology

Karolina Kopańska
Thomas Hartung

Frontiers in Toxicology

doi 10.3389/ftox.2026.1790669

1,124 views

Original Research

Accepted on 29 Apr 2026

Biochemical and Genomic Characterization of Last-Resort Antibiotic Resistance and Oxidant Tolerance in Environmental E. coli

in Environmental Toxicology

Asmaa Al-Mesaifri
Reem Ali
Abdallah Alhaj Sulaiman
Mustapha Aouida
Nisar Ahmed
Dindial Ramotar

Frontiers in Toxicology

207 views

Original Research

Accepted on 29 Apr 2026

Animal-Free Matrix Alternative for Three-Dimensional In Vitro Angiogenesis Models

in In Vitro Toxicology

Elle Koivunotko
Chris S. Pridgeon
Lauri Paasonen
Riina Harjumäki

Frontiers in Toxicology

205 views

Review

Published on 29 Apr 2026

Toxic or non-toxic: a critical assessment of the contradictory results for selected graphene family materials

in Nanotoxicology

Charlene Andraos
Victor Wepener
Mary Gulumian

Frontiers in Toxicology

doi 10.3389/ftox.2026.1818582

498 views

Mini Review

Accepted on 28 Apr 2026

Entangled Stressors: A review on the interactions between microplastics and climate change in aquatic ecosystems

in Environmental Toxicology

Jeffrey Lebepe
Nana Millicent Duduzile Buthelezi
Madira C Manganyi

Frontiers in Toxicology

177 views

Opinion

Accepted on 28 Apr 2026

Precaution with standards: Rethinking respiratory sensitization classification through the case of Methyl Methacrylate

in Regulatory Toxicology

Frank Faulhammer

Frontiers in Toxicology

216 views

Methods

Accepted on 28 Apr 2026

Compositional Profiling for Biodegradable Medical Devices: A Framework for Degradation-Informed Exposure and Risk Assessment

in Regulatory Toxicology

Jared Timothy Wilsey
Inga Potapova
Shaoping Wu
Mao-wen Weng
Matt Lewis
Haibo Wang
Echoleah Rufer
Dan Bellows
Marika Kamberi

Frontiers in Toxicology

174 views

Original Research

Published on 28 Apr 2026

A new in vitro rat liver platform capturing biological diversity for drug-induced liver injury assessment and reduction of animal use in drug discovery and development

in In Vitro Toxicology

Pralhad Wangikar
Sara Cherradi
Pradhnya Choudhari
Aditi Wangikar
Vaibhav Madiwal
Salomé Roux
Nisha Banerjee
Pranav Panzade
Pallavi Gangarde
Nithish Kannan

Frontiers in Toxicology

doi 10.3389/ftox.2026.1784229

605 views

Original Research

Accepted on 27 Apr 2026

Distinct pro-inflammatory responses to pristine and microbially contaminated PET nanoplastics in a human alveolar cell co-culture

in Environmental Toxicology

Øyvind P. Haugen
Andreas Sagen
Francesco Barbero
Victor Alcolea-Rodriguez
Raquel Portela
Ivana Fenoglio
Bendik C. Brinchmann
Håkan Wallin
Shan Narui
Anani K. Afanou

Frontiers in Toxicology

213 views

Review

Accepted on 27 Apr 2026

Airborne metals and malignant pleural effusions: The role of oxidative stress

in Environmental Toxicology

JESÚS VALENCIA
Martha Patricia Sierra-Vargas

Frontiers in Toxicology

189 views

719 articles

articles

Next-generation full-thickness human skin models produced using 3D electrospun scaffolds and animal-component-free culture media

Botulinum toxin type E alleviates trigeminal neuropathic pain via modulation of the HIF-1α–NLRP3 pathway

Challenges and solutions in transitioning to animal-free standards: a comprehensive analysis of components in human cell-based developmental neurotoxicity assays

PFOA/PFOS induce ferroptosis in bladder epithelial cells through inhibition of ACSL4 ubiquitination

Machine learning-integrated network toxicology uncovers glioma targets of DEHP

Molecular mechanisms of DEHP-associated neuroblastoma: an integrated network toxicology and molecular experimental investigation

Foodborne Illness Outbreaks Attributed to Chemical Hazards in the United States, 2011-2025

Impact of Liquid Dosing and Associated Cell 'Drowning' in a 3D Human Bronchial Epithelial Model used for Protease Exposure Studies

Irreversible Dialysis-dependent Acute Tubular Necrosis caused by standard-dose of Carboplatin: a case report

Hyperbaric Oxygen Therapy for Ischemic Encephalopathy Following Occupational Exposure to High-Concentration Toxic Gases: Two Case Reports

Evaluation and Investigation of the Cardiotoxicity of the Potential Anti-Cholangiocarcinoma Drug Lanatoside C

Toxicological Impacts of Environmentally Equivalent Microplastics and Cadmium Co-exposure in Tropical Freshwater Crab Sartoriana spinigera

Bridging gaps between scientific research and regulatory decision-making in Europe: roles of academia, risk assessors, and policymakers

Visual–acoustic thigmotaxis in zebrafish larvae: a high throughput NAM for neurotoxicity assessment

Next generation validation for next generation risk assessment

Biochemical and Genomic Characterization of Last-Resort Antibiotic Resistance and Oxidant Tolerance in Environmental E. coli

Animal-Free Matrix Alternative for Three-Dimensional In Vitro Angiogenesis Models

Toxic or non-toxic: a critical assessment of the contradictory results for selected graphene family materials

Entangled Stressors: A review on the interactions between microplastics and climate change in aquatic ecosystems

Precaution with standards: Rethinking respiratory sensitization classification through the case of Methyl Methacrylate

Compositional Profiling for Biodegradable Medical Devices: A Framework for Degradation-Informed Exposure and Risk Assessment

A new in vitro rat liver platform capturing biological diversity for drug-induced liver injury assessment and reduction of animal use in drug discovery and development

Distinct pro-inflammatory responses to pristine and microbially contaminated PET nanoplastics in a human alveolar cell co-culture

Airborne metals and malignant pleural effusions: The role of oxidative stress