Frontiers in Toxicology

Original Research

Published on 18 Dec 2025

Beyond cytotoxicity: pollutant mixtures elicit unconventional epithelial-fibroblast signaling in a human lung air-liquid interface co-culture model

in In Vitro Toxicology

Justine Fredoc-Louison
Maëva Cherrière
Bastien Rival
Suzanne De Araujo
Sabine François
Samir Dekali

Frontiers in Toxicology

doi 10.3389/ftox.2025.1722968

183 views

Original Research

Published on 18 Dec 2025

MoltiTox: a multimodal fusion model for molecular toxicity prediction

in Computational Toxicology and Informatics

Junwoo Park
Sujee Lee

Frontiers in Toxicology

doi 10.3389/ftox.2025.1720651

287 views

Case Report

Published on 17 Dec 2025

Alcohol-clozapine synergism triggering rhabdomyolysis at subtoxic levels: a case report and literature review

in Clinical Toxicology

Wenzhen Zhou
Yuxin Sun
Mingcheng Dai
Senlin Ma
Qiuxin Lu
Junwei Qian
Zhaoming Shang
Kangshuai Zhou
Mingquan Chen
Xiaofei Jiang

Frontiers in Toxicology

doi 10.3389/ftox.2025.1692362

370 views

Review

Published on 17 Dec 2025

Mechanistic read-across comes of age: a comparative appraisal of EFSA 2025 guidance, ECHA’s RAAF, and good read-across practice

in Regulatory Toxicology

Thomas Hartung
Costanza Rovida

Frontiers in Toxicology

doi 10.3389/ftox.2025.1690491

560 views

Correction

Published on 16 Dec 2025

Correction: The impact of perfumes and cosmetic products on human health: a narrative review

in Environmental Toxicology

Sharifa Alblooshi

Frontiers in Toxicology

doi 10.3389/ftox.2025.1713750

633 views

Mini Review

Accepted on 15 Dec 2025

Beyond the amyloid hypothesis: Leveraging human-centered complex in vitro models to decode Alzheimer's disease etiology

in In Vitro Toxicology

Matthew Price
Francesca Pistollato

Frontiers in Toxicology

157 views

Review

Accepted on 12 Dec 2025

Food Contaminants: Mechanisms of toxicity, computational assessment, and mitigation

in Computational Toxicology and Informatics

Laura Escorihuela Marti
Rajesh Kumar Pathak
Benjamí Martorell Masip
Vikas Kumar

Frontiers in Toxicology

Review

Accepted on 11 Dec 2025

The Zebrafish in Toxicology: A Bibliometric Analysis Reveals Current Trends and Future Avenues for Predictive Safety Assessment

in Developmental and Reproductive Toxicology

Carla Lima
Darlan Gusso
Geonildo Rodrigo Disner
Felipe Pinto
Maria Alice Pimentel Falcão
João Gabriel Santos ROSA
Mônica Lopes-Ferreira

Frontiers in Toxicology

101 views

Review

Published on 10 Dec 2025

Enhancing allergenicity risk assessment for novel foods in the EU: insights from the updated EFSA guidance - requirements, knowledge gaps and research needs

in Food and Nutritional Toxicology

Marcello Laganaro
Anna-Maria Pieger
Alejandra Muñoz-González
Estefanía Noriega Fernández
Ermolaos Ververis
Andrea Germini
Antonio Fernández Dumont

Frontiers in Toxicology

doi 10.3389/ftox.2025.1701391

910 views

Original Research

Published on 08 Dec 2025

Comparative evaluation of artificial saliva and complete artificial saliva as solvent vehicles for in vitro toxicity testing of oral tobacco products

in In Vitro Toxicology

Xuefei Cao
Mariana T. Farcas
Yevgeniya V. Prepelitskaya
Abaigeal Ritzenthaler
Jennifer Molignano
Jonathan Oldach
Marisol M. Gutierrez

Frontiers in Toxicology

doi 10.3389/ftox.2025.1657073

540 views

Case Report

Published on 05 Dec 2025

Cortical microstructural change linked to clinical recovery in subacute delayed encephalopathy after acute carbon monoxide poisoning: a longitudinal case report

in Clinical Toxicology

Takehiro Tamura
Yuka Fujimoto
Hironobu Nakamura
Yuki Takahashi
Junya Fujino
Shunsuke Takagi
Hidehiko Takahashi
Genichi Sugihara

Frontiers in Toxicology

doi 10.3389/ftox.2025.1701308

449 views

Data Report

Published on 05 Dec 2025

Wild mushroom poisoning in Mengzi city, Yunnan province, China, 2018–2023: an analysis through epidemiological characteristics and time series analysis with SARIMA and holt-winters models

in Food and Nutritional Toxicology

Rong Niu
Yimin Wang

Frontiers in Toxicology

doi 10.3389/ftox.2025.1705460

429 views

Original Research

Published on 05 Dec 2025

Thai rice instant granules containing turmeric extract and Phyllanthus emblica fruit pulp: Chronic toxicity and antioxidant profiles in rats and in silico investigation of bioactive compounds

in Food and Nutritional Toxicology

Charatda Punvittayagul
Atigan Thongtharb
Sonthaya Umsumarng
Siripat Chaichit
Siriporn Okonogi
Chadarat Ampasavate
Darunee Hongwiset
Sirinya Taya

Frontiers in Toxicology

doi 10.3389/ftox.2025.1691014

398 views

Original Research

Published on 04 Dec 2025

Monocyte migration assay using a vascular-on-a-chip model and its utilization for the evaluation of a heated tobacco product

in In Vitro Toxicology

Ayaka Hayashida
Atsuko Nozawa
Shigeaki Ito

Frontiers in Toxicology

doi 10.3389/ftox.2025.1658093

593 views

Original Research

Published on 04 Dec 2025

Simulation of microplastic transport and dispersion based on a three-dimensional hydrodynamic particle-tracking model in the Beibu Gulf

in Nanotoxicology

Changhao Sun
Yao Guan
Wenhao Hou
Huihua Wei
Xiaowei Hu
Huichang Jiang
Qiongyuan Su
Xiong Zhou
Jie Chen
Zuhao Zhu

Frontiers in Toxicology

doi 10.3389/ftox.2025.1676823

501 views

Original Research

Published on 03 Dec 2025

Retrospective analysis of clinical laboratory parameters in Han Wistar rat controls

in Computational Toxicology and Informatics

Rupert Kellner
Alexander Amberg
Frank Bringezu
Dragomir Ivanov Draganov
Annika Kreuchwig
Wolfgang Muster
Guillemette Duchateau-Nguyen
Nils Oberhauser
Paolo Piraino
Markus Schaefer

Frontiers in Toxicology

doi 10.3389/ftox.2025.1684191

434 views

Review

Published on 02 Dec 2025

Advancements in the in vitro culture of human pluripotent stem cells: progress, challenges, and future directions: comprehensive review

in In Vitro Toxicology

Niraj Chaudhary
Luis G. Villa-Diaz

Frontiers in Toxicology

doi 10.3389/ftox.2025.1667573

837 views

Original Research

Accepted on 01 Dec 2025

Nicotine-free electronic vape fluid stimulates angiogenic processes in vitro through ARF6-mediated oxidative stress

in In Vitro Toxicology

Lewis Spurrier-Best
David Butcher
Evangelene Blackham-Hayward
Zsuzsanna Kertesz
Havovi Chichger

Frontiers in Toxicology

215 views

Original Research

Accepted on 30 Nov 2025

Evaluating chemotherapy-driven placental alterations and their impact on fetal development

in Developmental and Reproductive Toxicology

Katrien De Clercq
Carolina Velazquez
Eleonora Persoons
Vera Elena Renée Annechien Wolters
Marieke van de Ven
Ji-Ying Song
Frédéric Amant

Frontiers in Toxicology

198 views

Original Research

Accepted on 27 Nov 2025

Short-chain PFAS exposure during gestation and breastfeeding alters learning and memory in adulthood: possible mechanisms related to brain development

in Developmental and Reproductive Toxicology

Luca Lorenzini
Marzia Moretti
Claudia Zanardello
Federica Gallocchio
Vito Antonio Baldassarro
Alessandra Moressa
Lorenzo Zanella
Michele Sannia
Greta Foiani
Corinne Quadalti

Frontiers in Toxicology

275 views

Original Research

Published on 27 Nov 2025

Unseen contaminants in Portuguese reservoirs: linking microplastics to ecological potential and human pressures

in Environmental Toxicology

C. Guimarães
I. Pinto
J. A. Padilha
S. C. Antunes

Frontiers in Toxicology

doi 10.3389/ftox.2025.1705228

663 views

Original Research

Published on 27 Nov 2025

Hazard identification and characterization of leachable chemicals from plastic products – a new PARC project

in Developmental and Reproductive Toxicology

Hubert Dirven
Aleksandra Bogusz
Hans Bouwmeester
Mathias Busch
Guillaume Duflos
Gunnar S. Eriksen
Margarida Fardilha
Daniela Flores-Gomez
Nina Franko
Laurent Gaté

Frontiers in Toxicology

doi 10.3389/ftox.2025.1719035

1,432 views

Original Research

Published on 26 Nov 2025

AlCl3 exposure induces nephrotoxicity in mice by mediating ferroptosis through the NRF2 signaling pathway

in Environmental Toxicology

Liu-Dan Liang
Xiao-Yue Zhao
Li Li
Sheng Liang
Jin-Min Zhang
Jian-Nan Lv
Feng-Lian Deng
Chun-Lei Lu
Qian Li
Qi-Wen Huang

Frontiers in Toxicology

doi 10.3389/ftox.2025.1692410

774 views

Original Research

Accepted on 24 Nov 2025

Imidacloprid Exposure in Rats Induces Cardiac Inflammatory Response through Activating TLR4/NF-κB/NLRP3 and JAK/STAT Signaling Pathways: Focus on the Berberine-Loaded Nanoliposomes

in Environmental Toxicology

Layla Alkharashi
Amina Farag
Noha Mohsen Gamil
Yasmen Mahran
Amira M. Badr
Heba Bayoumi
Mahmoud Mohamed
Awatif Binmughram
Aljawharah Alquhayz
Ghada BinOaeid

Frontiers in Toxicology

194 views

612 articles

articles

Beyond cytotoxicity: pollutant mixtures elicit unconventional epithelial-fibroblast signaling in a human lung air-liquid interface co-culture model

MoltiTox: a multimodal fusion model for molecular toxicity prediction

Alcohol-clozapine synergism triggering rhabdomyolysis at subtoxic levels: a case report and literature review

Mechanistic read-across comes of age: a comparative appraisal of EFSA 2025 guidance, ECHA’s RAAF, and good read-across practice

Correction: The impact of perfumes and cosmetic products on human health: a narrative review

Beyond the amyloid hypothesis: Leveraging human-centered complex in vitro models to decode Alzheimer's disease etiology

Food Contaminants: Mechanisms of toxicity, computational assessment, and mitigation

The Zebrafish in Toxicology: A Bibliometric Analysis Reveals Current Trends and Future Avenues for Predictive Safety Assessment

Enhancing allergenicity risk assessment for novel foods in the EU: insights from the updated EFSA guidance - requirements, knowledge gaps and research needs

Comparative evaluation of artificial saliva and complete artificial saliva as solvent vehicles for in vitro toxicity testing of oral tobacco products

Cortical microstructural change linked to clinical recovery in subacute delayed encephalopathy after acute carbon monoxide poisoning: a longitudinal case report

Wild mushroom poisoning in Mengzi city, Yunnan province, China, 2018–2023: an analysis through epidemiological characteristics and time series analysis with SARIMA and holt-winters models

Thai rice instant granules containing turmeric extract and Phyllanthus emblica fruit pulp: Chronic toxicity and antioxidant profiles in rats and in silico investigation of bioactive compounds

Monocyte migration assay using a vascular-on-a-chip model and its utilization for the evaluation of a heated tobacco product

Simulation of microplastic transport and dispersion based on a three-dimensional hydrodynamic particle-tracking model in the Beibu Gulf

Retrospective analysis of clinical laboratory parameters in Han Wistar rat controls

Advancements in the in vitro culture of human pluripotent stem cells: progress, challenges, and future directions: comprehensive review

Nicotine-free electronic vape fluid stimulates angiogenic processes in vitro through ARF6-mediated oxidative stress

Evaluating chemotherapy-driven placental alterations and their impact on fetal development

Short-chain PFAS exposure during gestation and breastfeeding alters learning and memory in adulthood: possible mechanisms related to brain development

Unseen contaminants in Portuguese reservoirs: linking microplastics to ecological potential and human pressures

Hazard identification and characterization of leachable chemicals from plastic products – a new PARC project

AlCl3 exposure induces nephrotoxicity in mice by mediating ferroptosis through the NRF2 signaling pathway

Imidacloprid Exposure in Rats Induces Cardiac Inflammatory Response through Activating TLR4/NF-κB/NLRP3 and JAK/STAT Signaling Pathways: Focus on the Berberine-Loaded Nanoliposomes