The Neurotoxicology section aims to provide an open access platform in the field of neurotoxicology with a focus on human relevance. Neurotoxicology is defined as the science that deals with the adverse effects of chemical, biological or physical elements on the nervous system. In addition to harmful direct effects there is increasing awareness that exposure to such noxae might induce long-term adversity to the nervous system by contributing to neurological disorders, such as Alzheimer’s or Parkinson’s disease, dementia, autism and attention deficit hyperactivity disorders (ADHD).Read More
Our mission is to build an open access platform in the field of Neurotoxicology with a focus on human relevance. Neurotoxicology is defined as the science that deals with the adverse effects of chemical, biological or physical elements on the nervous system. In addition to harmful direct effects there is increasing awareness that exposure to such noxae might induce long-term adversity to the nervous system by contributing to neurological disorders, such as Alzheimer’s or Parkinson’s disease, dementia, autism and attention deficit hyperactivity disorders (ADHD). However, we often lack a mechanistic understanding on how these compounds impact disease. Mechanisms of toxicity or disease are commonly complex because the nervous system is the most multifaceted organ of the human body. Thus, a broad range of expertise and evidence is needed that enhances our understanding of its vulnerability, function and responses to environmental or medical exposure.
Lessons from high attrition rates during the drug development process concerning the nervous system teach us the human uniqueness of brain physiology and pathology. Therefore, we encourage the authors of publications submitted to Neurotoxicology to emphasize human relevance in their studies. This can be approached in different ways including e.g. use of human-relevant cell systems, showing/discussing translation of animal studies to human physiology or pathology, extrapolating human-relevant exposure, or performing epidemiological studies. Publication of data without human translation is not supported.
To promote the translation of Neurotoxicity to human adverse outcomes, the Neurotoxicology section encourages submission of manuscripts contributing to:
• Mechanistic understanding of human adverse effects induced by xenobiotics or other noxae on the nervous system
• New Approach Methods (NAMs) to assess neurotoxicity and developmental neurotoxicity
• Risk assessment, risk management, and regulation of compounds with a potential target of the nervous system
• Epidemiological studies of (developmental) neurotoxicants
• Biomarkers of neurotoxicity
• Species differences in their susceptibility to neurotoxic compounds
• Development of Adverse Outcome Pathways (AOPs) for (developmental) neurotoxicity
• High-content and high-throughput methods to measure neurotoxicity in vitro
• Disease models for neurodevelopment or neurodegeneration
• Gene-environment interaction
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Neurotoxicology welcomes submissions of the following article types: Brief Research Report, Correction, Editorial, General Commentary, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review and Specialty Grand Challenge.
All manuscripts must be submitted directly to the section Neurotoxicology, where they are peer-reviewed by the Associate and Review Editors of the specialty section.
Articles published in the section Neurotoxicology will benefit from the Frontiers impact and tiering system after online publication. Authors of published original research with the highest impact, as judged democratically by the readers, will be invited by the Chief Editor to write a Frontiers Focused Review - a tier-climbing article. This is referred to as "democratic tiering". The author selection is based on article impact analytics of original research published in all Frontiers specialty journals and sections. Focused Reviews are centered on the original discovery, place it into a broader context, and aim to address the wider community across all of Toxicology.
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