1,201 news posts in Mind and body

Health

12 Jan 2023

Simple blood test shows promise for screening common and dangerous pregnancy complications

By Angharad Brewer Gillham, Frontiers science writer Image/Shutterstock.com Scientists find that short-chain fatty acids in blood can be used as biomarkers in testing for dangerous pregnancy complications such as pre-eclampsia, gestational diabetes and intrahepatic cholestasis of pregnancy. Scientists at Ningbo University, China have identified biomarkers that could provide an early warning system for three common and dangerous pregnancy complications: pre-eclampsia, gestational diabetes, and a liver condition called intrahepatic cholestasis. All three conditions are dangerous; early diagnosis and treatment is key to preventing poor outcomes and lifelong consequences. Their causes are not fully understood, and nor is their connection to the gut microbiome, which is affected by pregnancy and pregnancy-related conditions. A team led by Dr Siqian Chen at the Affiliated Hospital of Medical School decided to investigate whether specific changes in the microbiome — detected using levels of short-chain fatty acids, metabolites which are produced following the fermentation of microbiota — could be used as biomarkers for pregnancy complications. “We analyzed and correlated the distribution of short-chain fatty acids during normal pregnancy and during three specific types of complicated pregnancy, gestational diabetes, pre-eclampsia, and intrahepatic cholestasis,” said Dr Rongrong Xuan, senior author of the study, published today in Frontiers in […]

Health

09 Jan 2023

Eating almonds daily boosts exercise recovery molecule by 69% among ‘weekend warriors’

By Mischa Dijkstra, Frontiers science writer A new randomized controlled trial showed that participants who daily ate 57g almonds over four weeks had a 69% higher level of the beneficial oxylipin molecule 12,13-dihydroxy-9Z-octadecenoic acid in their blood after a 90 minute session of eccentric exercise than control volunteers. In contrast, they had a 40% lower level of the mildly toxic 9,10-Dihydroxy-12-octadecenoic acid in their blood after exercise than control participants. The authors conclude that daily consumption of almonds changes the metabolism to recover faster after strenuous exercise. For those who exercise regularly, eating almonds each day might be the ideal new year’s resolution. A randomized controlled trial in Frontiers in Nutrition showed that female and male participants who ate 57g almonds daily for one month had more of the beneficial fat 12,13-dihydroxy-9Z-octadecenoic acid (12,13-DiHOME) in their blood immediately after a session of intense exercise than control participants. This molecule, a so-called oxylipin (oxidized fat) is synthetized from linoleic acid by brown fat tissue, and has a beneficial effect on metabolic health and energy regulation. Corresponding author Dr David C Nieman, a professor and director of the Appalachian State University Human Performance Laboratory at the North Carolina Research Campus, said: “Here […]

Health

20 Dec 2022

Lonely heart-failure patients face worse outcomes than sociable peers

by Tania Fitzgeorge-balfour, science writer Social frailty, which includes the loss of social roles, social networks, and social activities, is widely identified as a risk to healthy aging. A new study is the first to show a close association between the loss of perceived social role amongst friends and family and poor clinical outcomes for older heart failure patients. These findings suggest that social engagement and activities should form part of the aftercare program for these patients. Older heart failure patients who feel that they have lost their social role amongst friends and family are more likely to suffer poor clinical outcomes. This is the finding of a new study in Frontiers in Cardiovascular Medicine that has examined the specific aspects of social interaction that can lead to a poor prognosis for these patients. “We are the first to show a close association between the loss of perceived social role and long-term poor clinical outcomes in older heart failure patients,” said Dr Satoshi Katano, first author of this research, based at Sapporo Medical University Hospital, Sapporo, Japan. “Our study highlights the real need to develop a management program that includes a social approach to the care of these patients.” Read […]

Life sciences

16 Dec 2022

Screening a puppy’s DNA methylome may help predict how energetic or fearful they will be

By Mischa Dijkstra, Frontiers science writer Scientists found that differences in the epigenome, in particular the DNA methylome, are predictably associated with differences in the temperament of dogs, especially their energy and fearfulness. The DNA methylome predicted these traits better than Single-Locus Polymorphisms or age. In future, breeders could screen the epigenome of puppies to find the best candidates for companion or service dogs. Anyone who’s ever had a dog knows how different one can be from another. For example, they can be reserved or friendly, playful or calm, fearful or bold, and prone to bark or fetch or not. Research has shown that some of these differences are genetically determined. But even within dog breeds, where line breeding and artificial selection have led to the loss of much of the original genetic variation, the behavior of individuals can differ widely. Now, researchers show that part of the differences in temperament – in particular their ‘energy’ level and fear-related behaviors – depend on acquired differences in the epigenome. The epigenome, an individual’s unique set of chemical tags on DNA and its associated histone complexes (nucleosomes), can dial the expression of local genes up or down. Because the epigenome is known […]

Neuroscience

15 Dec 2022

Five articles you need to check out on the future of neurology research

By Colm Gorey, Frontiers Science Communications Manager Image: Shutterstock.com In an ever-changing field of research such as neurology, it can be difficult to keep up with the latest breakthroughs. Now at Frontiers, we highlight just three of the latest research articles to shed more light on how the mind works. The human brain is an organ that has fascinated our species for centuries, with vast amounts of research so far yielding a wealth of discoveries. However, so much of how the brain works remains a mystery waiting to be solved. In 2022, Frontiers published one of the biggest neurological research breakthroughs of the year with the discovery that life may indeed flash before our eyes as we die. However, this was just one paper of thousands published by Frontiers this year that helped set the groundwork for new neurological discoveries, ranging from multiple sclerosis to deep brain stimulation. Five such articles are essential reading to anyone looking to learn more about neurology were published as part of the research topic ‘Horizons in Neurology’. The Neuroimmunology of Multiple Sclerosis: Fictions and Facts There have been tremendous advances in the neuroimmunology of multiple sclerosis (MS) over the past five decades, which have […]

Health

13 Dec 2022

The (un)fair allocation of scarce vaccines and how maths can provide a solution

By Prof Carlos Alós-Ferrer Prof Carlos Alós-Ferrer. Image: Nomis Foundation The Covid-19 global vaccine roll-out is considered one of the greatest achievements in modern medical history, saving hundreds of thousands of lives. However, it was marred by decisions that saw those most in need of a vaccine in some countries wait too long, while those perceived to be least at risk getting them first. Now, Prof Carlos Alós-Ferrer of the University of Zurich writes about how he and his colleagues’ latest research in Frontiers in Public Health shows that one maths procedure can ensure a fair distribution of scarce vaccines across the globe. Remember when Covid-19 vaccines first became available? After many months of lockdowns and increasing casualty rates, people across the planet were allowed to exhale a collective sigh of relief. However, as is always the case when new vaccines are developed, there were not enough doses for all who wanted them. Rationing had to be imposed. Unfortunately, the rationing procedures violated elementary ethical principles, which might have led to some elderly and at-risk patients being neglected while younger, healthier citizens were already vaccinated. How did it go wrong? Vaccine acquisition and allocation across the world was as centralized […]

Life sciences

09 Dec 2022

Evolution of bat wings and calls through ‘foraging syndromes’ allows diversity to flourish

By Mischa Dijkstra, Frontiers science writer Egyptian slit-faced bats, Nycteris thebaica In a new study, scientists show that the wing shape and the echolocation frequency of bats are tightly linked across species. This pattern could only be identified because of the large dataset in the present study, which allowed the authors to look beyond the effect of bat family on these traits. The results mean that wing shape and echolocation frequency have jointly evolved in response to foraging ecology, yielding an optimal combination of traits or ‘foraging syndrome’ in each habitat. Bats are an evolutionary success story. With approximately 1,400 species living today, they thrive in every environment except the polar regions. They come in a remarkable range of sizes, from the golden-crowned flying fox with a mass of 1.2 kg and a wingspan of 171 cm, to Kitti’s hog-nosed ‘bumblebee’ bat with a mass of 2 g and a wingspan of 33 cm. The frequencies that bats emit during echolocation are also highly variable, ranging from 11 kHz to 212 kHz. But what has driven the evolution of this extraordinary diversity? “Here we show with that among bat species, there is a close correspondence between wing shape and the […]

Health

07 Dec 2022

Could new cancer drugs come from potatoes and tomatoes?

by Angharad Brewer Gillham, Frontiers science writer Image/Shutterstock.com Polish scientists revealed the potential for new cancer drugs to be formulated from bioactive compounds found in plants from the genus Solanum, like potatoes and aubergines. Everyone knows someone who has had cancer. In 2020, around 19m new cases — and around 10m deaths — were registered worldwide. Treatments are improving all the time but can damage healthy cells or have severe side-effects which are hard on patients; in the search for new, more targeted cancer drugs, traditional medicine offers many possible candidates. A team of Polish scientists led by Magdalena Winkiel at Adam Mickiewicz University, publishing today in Frontiers in Pharmacology, reviewed the bioactive compounds called glycolalkaloids that are found in many vegetables that are household names, like potatoes and tomatoes, to demonstrate their potential to treat cancer. “Scientists around the world are still searching for the drugs which will be lethal to cancer cells but at the same time safe for healthy cells,” said Winkiel. “It is not easy despite the advances in medicine and powerful development of modern treatment techniques. That is why it might be worth going back to medicinal plants that were used years ago with success […]

Health

05 Dec 2022

Scientists find inorganic food additives might make babies more vulnerable to allergies

By Angharad Brewer Gillham, Frontiers science writer Image/Shutterstock.com Inorganic nanoparticles used to help process food may be crossing the placental barrier and getting into breastmilk, potentially damaging intestinal regulation and compromising babies’ oral tolerance, predisposing them to food allergies. Nanotechnologies have revolutionized food technology with changes to food production, manufacture, and processing that are intended to make our food safer and healthier. Phytosanitary products, processing aids, food additives, and surfaces that touch food in storage can all transfer nanoparticles that might be consumed by humans. In a review published in Frontiers in Allergy today, Mohammad Issa, at the Université Paris-Saclay, and colleagues pointed out that such a significant change to food production could have unforeseen health consequences. The team presented evidence that suggested that nanoparticles not only cross the placenta to reach developing fetuses but leave them at greater risk of potentially life-threatening food allergies. “Due to the immunotoxic and biocidal properties of nanoparticles, exposure may disrupt the host-intestinal microbiota’s beneficial exchanges and may interfere with intestinal barrier and gut-associated immune system development in fetus and neonate,” said Dr Karine Adel-Patient, corresponding author of the study. “This may be linked to the epidemic of immune-related disorders in children, such as […]

Health

30 Nov 2022

Biomarker in urine could be the first to reveal early-stage Alzheimer’s disease

By Conn Hastings, science writer Image: BlurryMe/Shutterstock.com Alzheimer’s disease can remain undetected until it is too late to treat. Large-scale screening programs could help to detect early-stage disease, but current diagnostic methods are too cumbersome and expensive. A new study published to Frontiers is the first to identify formic acid as a sensitive urinary biomarker that can reveal early-stage Alzheimer’s disease, potentially paving the way for inexpensive and convenient disease screening. Could a simple urine test reveal if someone has early-stage Alzheimer’s disease and could this pave the way for large-scale screening programs? A new study in Frontiers in Aging Neuroscience certainly suggests so. The researchers tested a large group of patients with Alzheimer’s disease of different levels of severity and healthy controls with normal cognition to identify differences in urinary biomarkers. They found that urinary formic acid is a sensitive marker of subjective cognitive decline that may indicate the very early stages of Alzheimer’s disease. Current methods to diagnose Alzheimer’s are expensive, inconvenient, and unsuitable for routine screening. This means that most patients only receive a diagnosis when it is too late for effective treatment. However, a non-invasive, inexpensive, and convenient urine test for formic acid could be […]

Psychology

24 Nov 2022

How you help a child go to sleep is related to their behavioral development, finds new study

By Suzanna Burgelman, Frontiers science writer Image: yamasan0708/Shutterstock.com A group of international researchers examined parental methods to help toddlers sleep across 14 cultures and found that these methods are related to the development of a child’s temperament. The researchers suggested focusing on better sleep-related parenting practices to support positive behavioral development across cultures. The importance of good sleep during childhood development has been extensively researched. Bad sleep quality and behaviors are detrimental to neurobehavioral functioning, emotional reactivity and regulation, and can pose a risk for future psychopathology. “Parental sleeping techniques are correlated with children’s sleep quality, and the importance of cultural context in child development has been long recognized,” said corresponding author Ms Christie Pham, of Washington State University. “We wanted to examine whether cross-cultural differences in parental sleep-supporting strategies account for differences in toddler temperament.” In a study published in Frontiers in Psychology, Pham and her colleagues studied the effect of different parental sleep-supporting techniques on child temperament across 14 cultures. They hypothesized that passive ways of helping a child fall asleep (eg, cuddling, singing, and reading), but not active methods (eg, walking, car rides, and playing), would be positively related to a child’s temperament. ► Read original article► Download original […]

Life sciences

23 Nov 2022

World’s heaviest flying bird may be self-medicating on plants used in traditional medicine

By Mischa Dijkstra, Frontiers science writer Great bustard male displaying on lek. Image credit: Carlos Palacín Researchers show that great bustards in Spain prefer to eat two plant species with compounds active in vitro against protozoa, nematodes, and fungi: corn poppies and purple viper’s bugloss. Males, who spend much time and energy on sexual displays during the mating season, have a stronger preference for these plants than females, and more so during the mating season than at other times of the year. The authors thus consider great bustards as prime candidates for non-human animals that self-medicate, but stress that more research is needed to definitively prove this. If you see a great bustard (Otis tarda) in the wild, you’re unlikely to forget it. Massive, colorful, and impossible to mistake, they are the heaviest birds living today capable of flight, with the greatest size difference between the sexes. They are also ‘lek breeders’, where males gather at chosen sites to put on an audiovisual show for the visiting females, who choose a mate based on his appearance and the quality of his showbirdship. But now, a study in Frontiers in Ecology and Evolution suggests that great bustards have another claim to […]

Health

15 Nov 2022

Balancing blood sugar: article collections on Diabetes

To mark World Diabetes Week, we have gathered our top article collections on Diabetes. With collective views of over 1.1 million, researchers explored topics spanning from stem cell technology for modelling Diabetes and the use of low carbohydrate diets for prevention to integrating digital health technologies in a patient-centered care framework and promising new therapeutic approaches in cardiovascular disease for diabetics. Article collections: Heart health 11 articles | 79,000 views Exploring the intimate relationship between cardiovascular disease and diabetes mellitus, highlighting key opportunities that may lead to promising new therapeutic approaches Alzheimer’s disease 6 articles | 80,000 views More than 35 million patients suffer from dementia, while 380 million battle against diabetes in this aging society. Emerging evidence suggests that diabetes increases the risk of dementia; however, the underlying mechanisms remain to be fully elucidated Patient Care 10 articles | 95,000 views Addressing the challenging and complex issues with Diabetes care, including improving and achieving effective and efficient care at the primary care setting as well as integrating digital health technologies in a patient-centered care framework Nutrition 7 articles | 79,000 views Examining the use of low carbohydrate diets, with or without nutritional ketosis, for the prevention and treatment of […]

Life sciences

11 Nov 2022

Having good friendships may make for a healthier gut microbiome

By Mischa Dijkstra, Frontiers science writer Grooming rhesus macaques on Cayo Santiago. Image credit: Lauren Brent Researchers show for the first time that monkeys that are more sociable – eg, grooming or being groomed more often, and with more grooming partners – have a healthier gut microbiome. For example, they have more of the beneficial bacteria Faecalibacterium and Prevotella, and fewer of the typically pathogenic bacteria Streptococcus. This is further evidence that in primates, social connectedness translates into good physical and mental health, and vice versa. Social connections are essential for good health and wellbeing in social animals, such as ourselves and other primates. There is also increasing evidence that the gut microbiome – through the so-called ‘gut-brain axis’ – plays a key role in our physical and mental health and that bacteria can be transmitted socially, for example through touch. So how does social connectedness translate into the composition and diversity of the gut microbiome? That’s the topic of a new study in Frontiers in Microbiology on rhesus macaques, Macaca mulatta. Lead author Dr Katerina Johnson, a research associate at the Department of Experimental Psychology and the Department of Psychiatry of the University of Oxford, said: “Here we show […]

Life sciences

04 Nov 2022

From ghost gear to microbe memories: 4 Frontiers articles you won’t want to miss

by Angharad Brewer Gillham, Frontiers science writer Image: Shutterstock.com At Frontiers, we bring some of the world’s best research to a global audience. But with tens of thousands of articles published each year, many often fly under the radar. Here are just four amazing papers you may have missed. The hunt for ghost gear 25-30% of the plastic waste in the sea is lost fishing gear, or ‘ghost gear’, some of it now up to 60 years old. This ghost gear devastates the environment not only through continuing to trap fish, but also by shedding microplastics into the environment which then enter the food chain. Once it sinks as far as the sea floor, it becomes invisible from above – a hidden threat to the marine ecosystem. A team led by Andrea Stolte from the World Wildlife Foundation, writing in Frontiers in Marine Science, reported a successful ghost-hunting collaboration between fisherfolk, scientists, and divers in the Baltic Sea. This coalition of stakeholders had several options for hunting down the ghost gear. Traditionally, when lost gear is spotted, fisherfolk use search hooks and other similar tools to try to retrieve it. However, this proved to be inefficient and damaging to the […]