Saliva sampling can be used as an alternative to blood sampling in therapeutic drug monitoring, pharmacokinetic and bioequivalence studies. There are many advantages to the use of saliva over plasma. For example, saliva samples are easier to collect compared to plasma samples. Furthermore, saliva is more reflective of samples free from pharmacologically-active components. According to the Salivary Excretion Classification System (SECS), excretion in the saliva is expected for classes I, II & III drugs but not class IV, according to drug effective permeability and plasma protein binding (as defined by Amidon clarification for principles of solubility and permeability).
Human clinical studies can face difficulties due to the need to take blood samples. The use of saliva sampling offers an easy and safe method, especially for use in paediatrics, geriatrics, and outpatients who need to give samples at home or work. Saliva samples are easy to store as they can be kept frozen until the time of the drug assay. An increase in the manufacture of drug assay kits using saliva samples is helping to encourage more research in the use of saliva.
The use of saliva in drug monitoring is becoming increasingly more beneficial because of the emergence of physiologically based pharmacokinetic (PBPK) modeling programs which can further aid in predicting drug exposure from saliva. The use of PBPK modelling is highly encouraged in this collection.
This Research Topic aims to assess the use of saliva sampling in drug monitoring as an alternative to the use of blood sampling. We welcome original research and review articles to assess the current observations in using saliva sampling. We also welcome clinical studies involving therapeutic drug monitoring, pharmacokinetics, and bioequivalence studies from saliva sampling in relation. Please not that reference to SECS is required. We also welcome researchers involved in manufacturing and testing of saliva-based kits to participate in this collection including research carried out to develop drug assay kits using saliva samples.
Saliva sampling can be used as an alternative to blood sampling in therapeutic drug monitoring, pharmacokinetic and bioequivalence studies. There are many advantages to the use of saliva over plasma. For example, saliva samples are easier to collect compared to plasma samples. Furthermore, saliva is more reflective of samples free from pharmacologically-active components. According to the Salivary Excretion Classification System (SECS), excretion in the saliva is expected for classes I, II & III drugs but not class IV, according to drug effective permeability and plasma protein binding (as defined by Amidon clarification for principles of solubility and permeability).
Human clinical studies can face difficulties due to the need to take blood samples. The use of saliva sampling offers an easy and safe method, especially for use in paediatrics, geriatrics, and outpatients who need to give samples at home or work. Saliva samples are easy to store as they can be kept frozen until the time of the drug assay. An increase in the manufacture of drug assay kits using saliva samples is helping to encourage more research in the use of saliva.
The use of saliva in drug monitoring is becoming increasingly more beneficial because of the emergence of physiologically based pharmacokinetic (PBPK) modeling programs which can further aid in predicting drug exposure from saliva. The use of PBPK modelling is highly encouraged in this collection.
This Research Topic aims to assess the use of saliva sampling in drug monitoring as an alternative to the use of blood sampling. We welcome original research and review articles to assess the current observations in using saliva sampling. We also welcome clinical studies involving therapeutic drug monitoring, pharmacokinetics, and bioequivalence studies from saliva sampling in relation. Please not that reference to SECS is required. We also welcome researchers involved in manufacturing and testing of saliva-based kits to participate in this collection including research carried out to develop drug assay kits using saliva samples.