Advances in inhalation safety assessment

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ORIGINAL RESEARCH

Published on 26 May 2025

Immunotoxicity assessment of multiwalled carbon nanotubes following whole-body inhalation exposure for 30 and 90 days in B6C3F1/N mice and 30 days in HSD:Harlan Sprague Dawley SD® rats

Victor J. Johnson
Nigel J. Walker
Michael I. Luster
Gary R. Burleson
Michelle Cora
Gregory L. Baker
Barney Sparrow
Dori R. Germolec

doi 10.3389/ftox.2025.1539810

248 views

ORIGINAL RESEARCH

Published on 21 Feb 2025

Evaluation of a non-animal toolbox informed by adverse outcome pathways for human inhalation safety

Renato Ivan de Ávila
Iris Müller
Hugh Barlow
Alistair Mark Middleton
Mathura Theiventhran
Danilo Basili
Anthony M. Bowden
Ouarda Saib
Patrik Engi
6 more
Maria Teresa Baltazar

doi 10.3389/ftox.2025.1426132

2,518 views

REVIEW

Published on 08 Oct 2024

New approach methodologies (NAMs) for the in vitro assessment of cleaning products for respiratory irritation: workshop report

Lynne T. Haber
Mark A. Bradley
Amanda N. Buerger
Holger Behrsing
Sabina Burla
Phillip W. Clapp
Scott Dotson
Casey Fisher
Keith R. Genco
7 more
Annie M. Jarabek

doi 10.3389/ftox.2024.1431790

2,877 views

CORRECTION

Published on 19 Jul 2024

Corrigendum: Applying new approach methodologies to assess next-generation tobacco and nicotine products

David Thorne
Damian McHugh
Liam Simms
K. Monica Lee
Hitoshi Fujimoto
Sara Moses
Marianna Gaca

doi 10.3389/ftox.2024.1460271

657 views

REVIEW

Published on 13 Jun 2024

Applying new approach methodologies to assess next-generation tobacco and nicotine products

David Thorne
Damian McHugh
Liam Simms
K. Monica Lee
Hitoshi Fujimoto
Sara Moses
Marianna Gaca

doi 10.3389/ftox.2024.1376118

3,242 views

ORIGINAL RESEARCH

Published on 11 Apr 2024

Use of quantitative in vitro to in vivo extrapolation (QIVIVE) for the assessment of non-combustible next-generation product aerosols

Marjory Moreau
Liam Simms
Melvin E. Andersen
Edgar Trelles Sticken
Roman Wieczorek
Sarah Jean Pour
Fiona Chapman
Karin Roewer
Sandra Otte
1 more
Matthew Stevenson

doi 10.3389/ftox.2024.1373325

2,395 views
6 citations

ORIGINAL RESEARCH

Published on 23 Jan 2024

Liquid application dosing alters the physiology of air-liquid interface (ALI) primary human bronchial epithelial cell/lung fibroblast co-cultures and in vitro testing relevant endpoints

Nicholas M. Mallek
Elizabeth M. Martin
Lisa A. Dailey
Shaun D. McCullough

doi 10.3389/ftox.2023.1264331

3,579 views
7 citations

ORIGINAL RESEARCH

Published on 05 Dec 2023

Refinement of the acute inhalation limit test for inert, nano-sized dusts by an in silico dosimetry-based evaluation: case study for the dissolution of a regulatory dilemma

Heidi Stratmann
Lan Ma-Hock
Simone Tangermann
Richard A. Corley

doi 10.3389/ftox.2023.1258861

1,299 views
1 citation

ORIGINAL RESEARCH

Published on 04 Sep 2023

Inhalation of electronic cigarettes slightly affects lung function and inflammation in mice

Yuxing Dai
Kun Duan
Guangye Huang
Xuemin Yang
Xingtao Jiang
Jianwen Chen
Peiqing Liu

doi 10.3389/ftox.2023.1232040

2,512 views
4 citations

ORIGINAL RESEARCH

Published on 16 Feb 2023

Twenty-eight day repeated exposure of human 3D bronchial epithelial model to heated tobacco aerosols indicates decreased toxicological responses compared to cigarette smoke

Fiona Chapman
Sarah Jean Pour
Roman Wieczorek
Edgar Trelles Sticken
Jessica Budde
Karin Röwer
Sandra Otte
Elizabeth Mason
Lukasz Czekala
3 more
Matthew Stevenson

doi 10.3389/ftox.2023.1076752

4,558 views
5 citations

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Frontiers in Toxicology

Immunotoxicology
In Vitro Toxicology
Environmental Toxicology

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Articles

Immunotoxicity assessment of multiwalled carbon nanotubes following whole-body inhalation exposure for 30 and 90 days in B6C3F1/N mice and 30 days in HSD:Harlan Sprague Dawley SD® rats

Evaluation of a non-animal toolbox informed by adverse outcome pathways for human inhalation safety

New approach methodologies (NAMs) for the in vitro assessment of cleaning products for respiratory irritation: workshop report

Corrigendum: Applying new approach methodologies to assess next-generation tobacco and nicotine products

Applying new approach methodologies to assess next-generation tobacco and nicotine products

Use of quantitative in vitro to in vivo extrapolation (QIVIVE) for the assessment of non-combustible next-generation product aerosols

Liquid application dosing alters the physiology of air-liquid interface (ALI) primary human bronchial epithelial cell/lung fibroblast co-cultures and in vitro testing relevant endpoints

Refinement of the acute inhalation limit test for inert, nano-sized dusts by an in silico dosimetry-based evaluation: case study for the dissolution of a regulatory dilemma

Inhalation of electronic cigarettes slightly affects lung function and inflammation in mice

Twenty-eight day repeated exposure of human 3D bronchial epithelial model to heated tobacco aerosols indicates decreased toxicological responses compared to cigarette smoke

Frontiers in Toxicology

Immunotoxicology

In Vitro Toxicology

Environmental Toxicology