Inflammatory bowel disease (IBD) is a chronic, relapsing, inflammatory disorder of the gastrointestinal tract that affects around 3.5 million people worldwide. Despite decades of intensive research, IBD treatment remains a serious medical challenge. The etiology of IBD remains uncertain, but it is believed to involve genetic, environmental, and microbial factors. IBD is thought to be initiated by an aberrant immune response to microbes and their products in a genetically susceptible host. The gut microbiota is shaped by environmental factors, such as diets. In addition, diets can affect the host at genomic, epigenomic, RNA, protein, and metabolism levels. In this regard, the Western diet, rich in fats and sugars, has been recognized as a major risk factor for IBD, but how the Western diet contributes to IBD is poorly understood. Therefore, this collection is intended to gather original research and review articles that focus on the roles of the Western diet in IBD.
Increasing evidence suggests that the Western diet is a major risk factor for IBD; however, the underlying mechanism is poorly understood. With the adaptation to the Western lifestyle and Western food, the incidence of IBD is increasing in Asian and African countries. Thus, there is a great interest to understand how the Western diet links to IBD. The goal of this collection is to publish articles that focus on dietary effects on the development or management of IBD. Topic editors aim to collect Original Research, Reviews, Mini Reviews, Case Studies, and Perspective Articles in this category.
The scope of this collection includes but not is limited to the following areas:
a. Effects of dietary compositions on IBD;
b. Dietary effects on the gut microbiome (colitogenic);
c. Dietary effects on host gene expression and epigenetics related to IBD;
d. Dietary effects on protein post-translational modifications related to IBD;
e. Dietary effects on microbial metabolites related to IBD;
f. Dietary effects on host metabolism related to IBD;
g. Population-based study focusing on the gut microbiome and IBD.
Keywords: nutritional immunology, IBS, IBD, Western Diet
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
