Exploring Infection Dynamics and Interventions in Pediatric Atopic Dermatitis

Atopic dermatitis, affecting 10% to 20% of children globally, is marked by chronic inflammation and varied complications, including infection risks. Although significant strides have been made in understanding and treating pruritus and allergic comorbidities, the complexities of infections associated with atopic dermatitis warrant deeper examination. These infections, differentiated into skin and extra-skin categories, are influenced by changes in the skin microbiome, the nuances of which are still partially understood. Furthermore, in the age of immunomodulatory treatments, the broader implications for infection risk and prevention strategies are emerging topics in research.

This Research Topic aims to delve into the intricate connection between atopic dermatitis and infections in children. It seeks to illuminate the clinical phenomena from both a preventative and therapeutic perspective, questioning whether microbiome-based therapies might redefine current treatment paradigms and how insights from other inflammatory conditions could inform these strategies.

To gather further insights into the relationship between atopic dermatitis and infections, we welcome articles addressing a variety of themes:
o Clinical, translational, and basic research that explores the relationship between atopic dermatitis, infections, and microbiome alterations.
o Detailed studies on skin and systemic infections pertinent to children with atopic dermatitis, such as cytomegalovirus infections or eczema herpeticum.
o Investigations into the temporal patterns of atopic dermatitis relative to infection occurrences.
o Analyses predicting infection risk and preventive measures tailored for children with moderate to severe atopic dermatitis.
o Exploration of emerging pathogens in the context of atopic dermatitis.
o The application of AI and machine learning in diagnosing and precisely managing atopic dermatitis.