The Role of Tumor Microenvironment in Malignant Progression and Target Validation

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ORIGINAL RESEARCH

Published on 30 May 2025

Hypoxia-induced tRF-3Thr-CGT promotes hepatocellular carcinoma progression via mitochondrial energy metabolism remodeling dependent on the mtDNA-translation mechanism

Xianzhi Qu
Buhan Liu
Duo Jin
Yue Ma
Mingjun Liu
Xiaoyu Yan
Jing Su
Lei Zhou

doi 10.3389/fphar.2025.1549373

220 views

REVIEW

Accepted on 29 May 2025

Targeting tumor-associated macrophages in gastric cancer progression and therapy: insights from molecular mechanisms to therapeutic applications

Yu Zhu
Xianbo Wu
Li Wan
Linyue Xu
Qiuyan Chen
Can Zou
Ju Huang

doi 10.3389/fphar.2025.1549694

ORIGINAL RESEARCH

Published on 03 Mar 2025

Multi-omics analysis of the dynamic role of STAR+ cells in regulating platinum-based chemotherapy responses and tumor microenvironment in serous ovarian carcinoma

Hongwei Lan
Weihua Yan
Xiao Huang
Jiali Cui
Helei Hou

doi 10.3389/fphar.2025.1545762

1,108 views

ORIGINAL RESEARCH

Published on 25 Feb 2025

Fenvalerate exposure induces AKT/AMPK-dependent alterations in glucose metabolism in hepatoma cells

Lu Sun
Zheng-Guo Cui
Qianwen Feng
Jibran Sualeh Muhammad
Yu-Jie Jin
Songji Zhao
Lingqi Zhou
Cheng-AI Wu

doi 10.3389/fphar.2025.1540567

1,021 views

ORIGINAL RESEARCH

Published on 04 Feb 2025

Exploring the anti-metastatic potential of sunitinib and novel analogs in colorectal cancer: insights into HIF-1α mediated metastasis

Fatemeh B. Rassouli
Maryam M. Matin
Farzin Hadizadeh
Masoud Nejabat
Hossein Allahverdizadeh
Hamidreza Jamali
Shahin Gharedaghi
Halimeh Hassanzadeh

doi 10.3389/fphar.2025.1520881

855 views

MINI REVIEW

Published on 11 Dec 2024

Cellular components of tumor microenvironment: understanding their role in lymphatic metastasis of tumors

Ziyi Wang
Zehui Li
Xiangyu Sun
Wanfu Men
Yan Xu

doi 10.3389/fphar.2024.1463538

1,034 views

OPINION

Published on 16 Sep 2024

Cholesterol metabolism: a positive target to revoke the function of exhausted CAR-NK cells in tumor microenvironment

Jingfeng Liu

doi 10.3389/fphar.2024.1440869

978 views
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Frontiers in Pharmacology

Pharmacology of Anti-Cancer Drugs

Participating Journals

Frontiers in Oncology
- Pharmacology of Anti-Cancer Drugs
- 3.5 impact factor
- 6.2 citescore

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Articles

Hypoxia-induced tRF-3Thr-CGT promotes hepatocellular carcinoma progression via mitochondrial energy metabolism remodeling dependent on the mtDNA-translation mechanism

Targeting tumor-associated macrophages in gastric cancer progression and therapy: insights from molecular mechanisms to therapeutic applications

Multi-omics analysis of the dynamic role of STAR+ cells in regulating platinum-based chemotherapy responses and tumor microenvironment in serous ovarian carcinoma

Fenvalerate exposure induces AKT/AMPK-dependent alterations in glucose metabolism in hepatoma cells

Exploring the anti-metastatic potential of sunitinib and novel analogs in colorectal cancer: insights into HIF-1α mediated metastasis

Cellular components of tumor microenvironment: understanding their role in lymphatic metastasis of tumors

Cholesterol metabolism: a positive target to revoke the function of exhausted CAR-NK cells in tumor microenvironment

Frontiers in Pharmacology

Pharmacology of Anti-Cancer Drugs

Participating Journals

Frontiers in Oncology

Pharmacology of Anti-Cancer Drugs