Prevention and Treatment of Metabolic Diseases Using Bioactive Metabolites of Herbal Medicines Also Used as Foods

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SYSTEMATIC REVIEW

Published on 14 Aug 2025

Metabolic dysfunction-associated fatty liver in type 2 diabetes mellitus patient: can a systematic review of and meta-analysis of commonly used TCM-preparation shed light on their efficacy?

Jingsi Cao
Tingting Bao
Jingxian Cao
Xuechun Fan
Yanyan Wang
Jing Yu
Ying Wang
RuiXue Deng
Jingjing Shi
2 more
Jia Mi

doi 10.3389/fphar.2025.1578371

248 views

CLINICAL TRIAL

Accepted on 28 Jul 2025

Citrus Flavonoid Supplement Enhances Glycemic and Metabolic Control in Prediabetic Patients on Metformin: A Randomized Controlled Trial

Thais Cesar
Maria Rita Marques Oliveira
Valeria Cristina Sandrim
Adriana Mendes
Ricardo Bruder
Rogerio Antonio De Oliveira
Katia Sivieri
Dragan Milenkovic

doi 10.3389/fnut.2025.1639901

274 views

ORIGINAL RESEARCH

Published on 06 Jun 2025

Hydroxysafflor yellow A alleviates oxidative stress and inflammatory damage in the livers of mice with nonalcoholic fatty liver disease and modulates gut microbiota

Liang Wu
Xueyun Dong
Wen Sun
Tan Jiajun
Asmaa Ali
Jiayuan He
Pingping Wang

doi 10.3389/fphar.2025.1568608

1,558 views

ORIGINAL RESEARCH

Published on 30 May 2025

Transcriptomic and metabonomic profiling unveils the mechanism of Tartary buckwheat and kiwi co-fermentation products in hyperlipidemia treatment

Nan Guohui
Xie Tingna
He Qinghui
Yu Hongchun
Peng Jing
Jiang Shiyin
Li Li
Yuan Huawei
Wei Daijing
Wu Qi

doi 10.3389/fphar.2025.1572593

790 views

ORIGINAL RESEARCH

Published on 25 Apr 2025

Therapeutic effects of medicinal and food-based traditional herbal couples on type 2 diabetes mellitus based on pharmacodynamics and pharmacokinetics

Yuhang Xu
Jing Li
Mengyao Cui
Xiaoliang Li
Hongyan Zhai
Deling Wu
Xiaoqin Chu

doi 10.3389/fphar.2025.1560271

1,543 views

ORIGINAL RESEARCH

Published on 22 Apr 2025

Delites™ supplementation prevents metabolic syndrome onset and modulates gut microbiome in male Sprague Dawley rats fed on cholesterol- and fat-enriched diet: a randomized preclinical trial study

Juan Leonardo
Robby Hertanto
Reggie Surya
Rony Abdi Syahputra
Wardina Humayrah
Nindy Sabrina
Nurpudji Astuti Taslim
Trina Ekawati Tallei
Raymond Rubianto Tjandrawinata
Fahrul Nurkolis

doi 10.3389/fnut.2025.1571473

1,368 views

ORIGINAL RESEARCH

Published on 09 Apr 2025

Targeted metabolomics unravels the mechanism by phenylpropanoid-rich of the peel of Zea mays L. ameliorates metabolic disorders in diabetic mice through gut microbiota modulation

Xiaotian Cheng
Jinyan He
Yuru Yang
Yaonan He
Guangtong Chen
Bai Ling
Andong Wang

doi 10.3389/fphar.2025.1551713

941 views

ORIGINAL RESEARCH

Published on 31 Mar 2025

The methodological reporting quality in strictly randomized controlled trials for COVID-19 and precise reporting of Chinese herbal medicine formula intervention

Min-Li Chen
Shi-Yan Qian
Jiang-Li Yang
Jue-Yan Zheng
Li-Xiang Wang
Jing-Ying Wu
Hai-Qin Ye
Yan Wang
Guo-Qing Zheng

doi 10.3389/fphar.2025.1532290

1,140 views

ORIGINAL RESEARCH

Published on 20 Feb 2025

Thonningianin A ameliorates acetaminophen-induced liver injury by activating GPX4 and modulating endoplasmic reticulum stress

Shanglei Lai
Yingyan Ye
Qinchao Ding
Xiaokai Hu
Ai Fu
Lan Wu
Wenjing Cao
Qingsheng Liu
Xiaobing Dou
Xuchen Qi

doi 10.3389/fphar.2025.1531277

1,563 views

ORIGINAL RESEARCH

Published on 13 Feb 2025

Network analysis and experimental validation to investigate chenpi against functional dyspepsia through TLR4/MyD88 by regulating the gut microbial structure

Jinfang Hu
Xu Wang
Xiaoqiu Guo
Wen Wen
Jin Xue
Zhengzheng Liao
Lihua Chen

doi 10.3389/fphar.2025.1495799

1,103 views

REVIEW

Published on 11 Feb 2025

Natural compounds in the management of polycystic ovary syndrome: a comprehensive review of hormonal regulation and therapeutic potential

Jingyi Yuan
Zhenmin Li
Yongjiang Yu
Xiuge Wang
Yunyun Zhao

doi 10.3389/fnut.2025.1520695

5,253 views
4 citations

ORIGINAL RESEARCH

Published on 07 Jan 2025

Portulaca oleracea L. (purslane) extract ameliorates intestinal inflammation in diet-induced obese mice by inhibiting the TLR4/NF-κB signaling pathway

Lingchao Miao
Meng Sam Cheong
Haolin Zhang
Haroon Khan
Hongxun Tao
Yuxiao Wang
Wai San Cheang

doi 10.3389/fphar.2024.1474989

1,105 views

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Frontiers in Nutrition
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Articles

Metabolic dysfunction-associated fatty liver in type 2 diabetes mellitus patient: can a systematic review of and meta-analysis of commonly used TCM-preparation shed light on their efficacy?

Citrus Flavonoid Supplement Enhances Glycemic and Metabolic Control in Prediabetic Patients on Metformin: A Randomized Controlled Trial

Hydroxysafflor yellow A alleviates oxidative stress and inflammatory damage in the livers of mice with nonalcoholic fatty liver disease and modulates gut microbiota

Transcriptomic and metabonomic profiling unveils the mechanism of Tartary buckwheat and kiwi co-fermentation products in hyperlipidemia treatment

Therapeutic effects of medicinal and food-based traditional herbal couples on type 2 diabetes mellitus based on pharmacodynamics and pharmacokinetics

Delites™ supplementation prevents metabolic syndrome onset and modulates gut microbiome in male Sprague Dawley rats fed on cholesterol- and fat-enriched diet: a randomized preclinical trial study

Targeted metabolomics unravels the mechanism by phenylpropanoid-rich of the peel of Zea mays L. ameliorates metabolic disorders in diabetic mice through gut microbiota modulation

The methodological reporting quality in strictly randomized controlled trials for COVID-19 and precise reporting of Chinese herbal medicine formula intervention

Thonningianin A ameliorates acetaminophen-induced liver injury by activating GPX4 and modulating endoplasmic reticulum stress

Network analysis and experimental validation to investigate chenpi against functional dyspepsia through TLR4/MyD88 by regulating the gut microbial structure

Natural compounds in the management of polycystic ovary syndrome: a comprehensive review of hormonal regulation and therapeutic potential

Portulaca oleracea L. (purslane) extract ameliorates intestinal inflammation in diet-induced obese mice by inhibiting the TLR4/NF-κB signaling pathway

Frontiers in Pharmacology

Ethnopharmacology

Participating Journals

Frontiers in Nutrition

Nutrition and Metabolism