Long-Term Clinical and Epidemiological Perspectives on Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)

This Research Topic centers on the ongoing impacts of COVID-19, particularly focusing on the Post-Acute Sequelae of SARS-CoV-2 infection (PASC). The field of infectious diseases has been profoundly affected by the COVID-19 pandemic, with PASC emerging as a critical area of concern due to its persistent health implications. Current studies have begun to delineate the prevalence and variability of PASC symptoms among different populations, but gaps remain in our understanding of its long-term effects and the factors influencing its progression. While researchers have identified potential biological and physiological contributors to PASC, comprehensive investigations into the socio-environmental aspects and their interaction with biological mechanisms are still needed.

This Research Topic aims to expand our knowledge on how PASC impacts individuals throughout their lives, emphasizing the evolution from acute infectious stages to chronic health issues. It seeks to uncover the underlying mechanisms that result in the continuity of symptoms and explores how these can inform targeted treatments and healthcare policies. Specifically, the goal is to pinpoint effective intervention strategies that could be pivotal in alleviating the long-term effects of PASC.

To gather further insights in this complex domain, we welcome articles addressing, but not limited to, the following themes:

Epidemiological Studies: Detailed studies on the demography of PASC, analyzing risk factors and long-term outcomes.

Biological Mechanisms: In-depth research into the pathophysiological continuities of PASC, focusing on immune responses and genetic factors.

Clinical Management and Intervention Trials: Novel insights into management tactics and therapeutic interventions aimed at reducing PASC's chronic impact.

Patient Trajectories and Life-Course Analysis: Comprehensive analyses of how PASC symptoms change, stabilize, or intensify through various life stages, including the impact on health and care services.

Healthcare System Response: Evaluations of how health systems adapt to and manage the long-term demands imposed by PASC, improving patient care and resource allocation.

Through a concentrated examination of these areas, this Research Topic will enhance our understanding of PASC within the framework of infectious diseases, contributing significantly to improved health outcomes for those suffering from long-term effects of COVID-19.

Keywords: PASC Epidemiology, Public Health, Strategies AI in Healthcare, Policy Interventions, Digital Health Solutions

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.