Real-World Evidence and its Impact on Sustainable Health Financing, Economics and Outcomes

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About this Research Topic

Submission deadlines

  1. Manuscript Summary Submission Deadline 10 August 2025 | Manuscript Submission Deadline 28 November 2025

  2. This Research Topic is still accepting articles.

Background

Real-world evidence (RWE), drawn from sources such as electronic health records, insurance claims, patient registries, and patient-reported outcomes, has become crucial in transforming healthcare systems toward greater sustainability. By capturing authentic clinical practice information, RWE reveals variations in patient demographics, comorbidities, adherence, and socioeconomic factors—critical for understanding how healthcare interventions function outside controlled trial environments. Contemporary research increasingly demonstrates that well-leveraged RWE can improve the assessment of healthcare interventions, particularly regarding their effectiveness, safety, and—crucially—cost-efficiency and equity in real-world settings. However, challenges persist in the systematic integration of RWE into policy, health financing, and resource allocation decisions, including issues of data quality, methodological rigor, and consistent translation of insights into financing and economic practice.

This Research Topic seeks to advance the understanding of how real-world data (RWD) informs sustainable health financing, economics, and outcomes. The collection will focus on innovative methodologies and analytical approaches that strengthen the value of RWE in guiding healthcare researchers, managers, payers, and policymakers in economic evaluation, budgeting, payment reforms, value-based decision-making, health promotion, and the improvement of health outcomes. Emphasis is placed on bridging the gap between research, health policy, population health improvement, and the efficient use of healthcare resources.

Key objectives include deepening knowledge of intervention impacts in everyday practice, promoting cost-effective and equitable resource utilization, and guiding sustainable health investment strategies. Integration across research, economic evaluation, policy planning, and clinical implementation will be encouraged to drive robust, sustainable healthcare solutions.

We invite articles addressing, but not limited to, the following themes:

Evaluating intervention impacts on healthcare economics and financing across diverse populations using real-world data.

Analyzing real-world diagnostic and treatment patterns, outcomes, and healthcare costs, with particular focus on policy-relevant social and economic determinants.

Identification and reduction of financial and access disparities related to healthcare utilization and outcomes.

Implementation and evaluation of innovative technologies and payment models to optimize patient care, improve equity, and ensure financial sustainability.

Clinical and economic assessments of emerging interventions and medical devices using RWE.

Leveraging RWD to enhance strategies for efficient healthcare resource allocation and value-based payment.

Assessing the impact of health policies on resource allocation, reimbursement, and technology diffusion using RWE frameworks.

Improving the relevance and applicability of health technology assessment findings to support sustainable financing and economic policymaking.

Through these shared perspectives, this Research Topic aims to further consolidate the essential role of real-world evidence in achieving sustainable health financing and advancing healthcare economics.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Community Case Study
  • Data Report
  • Editorial
  • General Commentary
  • Hypothesis and Theory
  • Methods
  • Mini Review
  • Opinion

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Keywords: Real-World Evidence (RWE), Health Services Innovation, Evidence-Based Decision-Making, Healthcare Disparities, Policy Impact Evaluation

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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