European Partnership on the Assessment of Risks from Chemicals (PARC): Continued Focus on New Approach Methodologies (NAMs) and Data Gap Filling

The European Partnership on the Assessment of Risks from Chemicals (PARC) was launched in 2022 to advance our understanding of chemical substances and better protect human health and the environment. As PARC reaches its halfway mark, new activities will be initiated to enhance our capacity to identify hazardous chemicals and implement strategies to minimize harm to humans and the environment. Activities will also further align chemical testing with the EU’s roadmap for phasing out animal testing in chemical toxicity assessments.


PARC is structured into several work packages (WPs), with WP5 focusing on hazard assessment for human and environmental health. This WP involves over 80 European partners and aims to address data gaps for chemicals of concern, as well as developing and improving new approach methodologies (NAMs) for hazard assessment. Given the intentionally evolving nature of PARC, presenting early initiatives has proven valuable in increasing awareness and integrating new activities as the project progresses.


This research topic will highlight new activities under PARC WP5, specifically efforts to develop NAMs and fill data gaps to enhance chemical risk assessment. We welcome original research, reviews, and perspectives that:



· Describe new activities under PARC WP5, scheduled to be initiated at the project’s half-way mark



· Present original research that aligns with WP5 activities and objectives



· Activities that report links between WP5 and other PARC WPs



· Discuss relevant NAM-related activities in risk assessment, also beyond WP5

Submissions to this topic are by invite only

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy and Practice Reviews
• Policy Brief
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Risk assessment; new approach methodologies; omics; endocrine disrupters.

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.