New Mechanisms for Anti-Cancer Drugs: Volume II

This Research Topic builds on the success of 'New Mechanisms for Anti-Cancer Drugs,' which highlighted advancements in understanding and targeting cancer through innovative approaches and novel therapeutic agents.

Cancer is the second leading cause of death. Every year, many anticancer drug candidates are discovered and synthesized, but the major challenge lies in identifying, characterizing and evaluating their efficacy.

The aim of this Research Topic, " Volume II: New Mechanisms for Anti-Cancer Drugs" is to build on the findings of Volume I and collect a group of publications focused on novel chemical compounds exhibiting new modes of actions and/or new target proteins to fulfill their cytotoxic activity on cancer cells. In this context, we will also be pleased to consider studies on drug repurposing, including approved, discontinued, and shelved drugs, when anti-cancer activity results from an unexpected mode of action.

The themes of this collection include but are not limited to the following areas:

•Inhibitors of new kinases relevant to cancer
•Drugs acting on new modes of cell death
•Drugs targeting tumor suppressor genes
•Cancer precision medicine with new targets
•Cancer immunotherapy inhibiting new checkpoint
•Metabolism-modulating anti-cancer drugs

This collection welcomes Original Research, Mini Reviews, Perspectives, and Methods.