Cancer is increasingly recognized as a systemic disease influenced by complex interactions between genetic, metabolic, immunologic, and environmental factors. Among these, nutritional status and metabolic health play a pivotal role in shaping disease progression and treatment response. Obesity and metabolic dysregulation, often driven by both genetic predispositions and lifestyle factors, are associated with poorer outcomes in oncology.
This Research Topic is dedicated to advance our understanding of how precision nutrition strategies can be integrated into oncology to improve the metabolic health, immune function, and ultimately the prognosis and quality of life of cancer patients. More specifically, we aim to explore how multiomic and multidimensional data—including genomics, epigenomics, metagenomics, biochemical markers, anthropometric data, physical activity, sleep patterns, and dietary habits—can be leveraged to better characterize the oncologic patient. By integrating these data layers, researchers can develop personalized nutrition interventions to restore metabolic health and immune function, offering a complementary approach to conventional cancer therapies.
We welcome contributions that investigate the role of gene-diet interactions, epigenetic modifications, and lifestyle factors in shaping metabolic health and immune responses in cancer. The ultimate goal is to foster the development of tailored nutritional strategies that enhance metabolic resilience, support immune competence, and improve clinical outcomes in oncology.
These strategies include: .-Optimization of metabolic health and control of meta-inflammation of cancer patients .-Enhanced immune system function and immunotherapy outcomes. .-Improvement of the nutritional health to mitigate treatment-related side effects. .-Personalize dietary recommendations to align with genetic, epigenetic and microbiome profiles.
We invite submissions of original research articles, reviews, mini-reviews, brief research reports, and short communications that address, but are not limited to, the following areas:
.-Genetic Predisposition and Immunometabolic Alterations in Cancer: Studies on how genetic variants influence susceptibility to metabolic and immune dysregulation in cancer patients. .-Nutrigenomics and Nutritional Modulation of Gene Expression: Research on how specific dietary components affect gene expression related to metabolism, inflammation, and immune function. .-Epigenetics and Diet in Cancer Progression Investigations into how dietary factors induce epigenetic changes (e.g., DNA methylation, histone modifications) that influence cancer development and progression. .-Multi-Omic and Multidimensional Patient Profiling: Integration of genomic, transcriptomic, proteomic, metabolomic, microbiome, and lifestyle data to improve patient stratification and nutritional intervention design. .-Personalized Nutrition Strategies in Oncology: Development and validation of individualized dietary plans based on multi-omic data to enhance metabolic and immune resilience. .-Mechanistic Insights into Diet-Gene Interactions: Experimental studies elucidating molecular pathways through which nutrition influences cancer biology. .-Diet and microbiome interactions in cancer
Please note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this Research Topic.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Classification
Clinical Trial
Editorial
FAIR² Data
General Commentary
Hypothesis and Theory
Methods
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Classification
Clinical Trial
Editorial
FAIR² Data
General Commentary
Hypothesis and Theory
Methods
Mini Review
Opinion
Original Research
Perspective
Review
Study Protocol
Systematic Review
Technology and Code
Keywords: Metabolic health, Nutrigenomics, Epigenetics, Microbiome, Risk factors in cancer, Precision Nutrition, immune system function, Molecular insights, diet-genes, cancer progression
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
