Cardiorenal Metabolic Health and Diabetic Nephropathy: Mechanisms, Biomarkers, and Therapeutic Advances

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ORIGINAL RESEARCH

Published on 12 Oct 2026

Taxifolin alleviates podocyte injury and macrophage chemotaxis associated with diabetic nephropathy by directly targeting RBP1 identified via multi-omics and machine learning

Zi-Xuan Wang
Wen-Xuan Wang
Qiong-Dan Liang
Ling-Dong Kong

doi 10.3389/fphar.2026.1933167

352 views

REVIEW

Published on 08 Oct 2026

Dickkopf-3 (DKK3) in cardiovascular diseases: from a stress-responsive biomarker to a potential therapeutic target

Xiaoyan Fu
Jianfeng Dai
Xiaoqian Wang
Libin Qiu
Yunkai Hua

doi 10.3389/fphar.2026.1842032

983 views

ORIGINAL RESEARCH

Published on 15 Sep 2026

Imeglimin may improve albuminuria associated with partial suppression of inflammatory and fibrotic markers in diabetic kidney disease

Yoshimi Muta
Hisashi Yokomizo
Takako Kawanami
Yuriko Hamaguchi
Dai Nagata
Mayuko Yamamoto
Yuki Senda
Yuichi Takashi
Shohta Kodama
Daiji Kawanami

doi 10.3389/fphar.2026.1895272

1,058 views

ORIGINAL RESEARCH

Published on 09 Sep 2026

Baicalein attenuates extracellular matrix remodeling via FN1 in diabetic kidney disease: a multi-omics, machine-learning and mesangial-cell rescue study

Yimin Li
Yuqing Tian
Zhenhua Wu
Fangyu Xia
Liyifan Zheng
Meifang Ren
Meijiao Zhao
Qian Zhang
Jinchuan Tan
1 more
Fengwen Yang

doi 10.3389/fphar.2026.1852694

941 views

REVIEW

Published on 08 Sep 2026

Diabetic kidney disease within the framework of cardio-kidney-metabolic health: a paradigm shift

Juarez R. Braga
Fatima Ayub
Srikanth Vallurupalli
Nithin Karakala
Joseph H. Holthoff

doi 10.3389/fphar.2026.1907928

877 views

REVIEW

Published on 21 Jul 2026

Zinc, type 2 diabetes, diabetic kidney disease: focus on hypoxia

Svetlana A. Lebedeva
Ekaterina M. Mikhailova
Maria Yu Materenchuk
Denis V. Kurkin
Mikhail Samsonov
Vadim V. Tarasov
Kerim Mutig

doi 10.3389/fendo.2026.1825409

1,221 views

ORIGINAL RESEARCH

Published on 07 Jul 2026

Inverse association of circulating kallikrein-related peptidase 7 with renal function and mortality risk in patients with chronic kidney disease

Robin Schürfeld
Fabian Baalmann
Ekaterine Baratashvili
Benjamin Sandner
Anette Bachmann
Juliane Weiner
Marleen Würfel
Ralph Wendt
Martin Haussmann
14 more
Thomas Ebert

doi 10.3389/fendo.2026.1804956

1,243 views

ORIGINAL RESEARCH

Published on 30 Jun 2026

Vitamin D deficiency and metabolic disorders increase albuminuria risk in type 2 diabetes (ACR 0.1–300 mg/g): a nomogram-based stratification

Yanmei Lin
Chenru Zhao
Kang Du
Jianqing Tian

doi 10.3389/fendo.2026.1818376

1,861 views

REVIEW

Published on 11 Jun 2026

Uric acid–associated mechanisms of coronary artery calcification in diabetic kidney disease: evidence, hypotheses, and translational perspectives

Shuangqing Li
Yan Liu

doi 10.3389/fcvm.2026.1798922

2,142 views

ORIGINAL RESEARCH

Published on 05 Jun 2026

Nomogram analysis of factors associated with prognosis in patients with sepsis-associated acute kidney injury: a case-control study based on LASSO regression

Kabinuer Keyimu
Palida Abulizi
Julaiti Rouzhahong
Chen Wei

doi 10.3389/fmed.2026.1838034

966 views

SYSTEMATIC REVIEW

Published on 20 May 2026

Prediction models for progression from diabetic kidney disease to end-stage renal disease: a systematic review and meta-analysis

Yang Shi
Zhaoxi Dong
Xiaomeng Shan
Xiqian Wang
Siyu Huang
Hongfang Liu
Linqi Zhang

doi 10.3389/fendo.2026.1812362

3,754 views
1 citation

ORIGINAL RESEARCH

Published on 08 May 2026

Therapeutic targets for diabetic nephropathy identified by druggable genome mendelian randomization: the role of the gut microbiota-metabolite axis

Ling Niu
Rong Ma
Cuijuan Miao
Fang Liu
Boyi Li

doi 10.3389/fendo.2026.1817400

1,864 views
1 citation

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Cardiorenal Metabolic Health and Diabetic Nephropathy: Mechanisms, Biomarkers, and Therapeutic Advances

Articles

Taxifolin alleviates podocyte injury and macrophage chemotaxis associated with diabetic nephropathy by directly targeting RBP1 identified via multi-omics and machine learning

Dickkopf-3 (DKK3) in cardiovascular diseases: from a stress-responsive biomarker to a potential therapeutic target

Imeglimin may improve albuminuria associated with partial suppression of inflammatory and fibrotic markers in diabetic kidney disease

Baicalein attenuates extracellular matrix remodeling via FN1 in diabetic kidney disease: a multi-omics, machine-learning and mesangial-cell rescue study

Diabetic kidney disease within the framework of cardio-kidney-metabolic health: a paradigm shift

Zinc, type 2 diabetes, diabetic kidney disease: focus on hypoxia

Inverse association of circulating kallikrein-related peptidase 7 with renal function and mortality risk in patients with chronic kidney disease

Vitamin D deficiency and metabolic disorders increase albuminuria risk in type 2 diabetes (ACR 0.1–300 mg/g): a nomogram-based stratification

Uric acid–associated mechanisms of coronary artery calcification in diabetic kidney disease: evidence, hypotheses, and translational perspectives

Nomogram analysis of factors associated with prognosis in patients with sepsis-associated acute kidney injury: a case-control study based on LASSO regression

Prediction models for progression from diabetic kidney disease to end-stage renal disease: a systematic review and meta-analysis

Therapeutic targets for diabetic nephropathy identified by druggable genome mendelian randomization: the role of the gut microbiota-metabolite axis

Frontiers in Pharmacology

Renal Pharmacology

Cardiovascular and Smooth Muscle Pharmacology