Novel Immunobiological Therapies for Pediatric Glomerular Diseases

Pediatric glomerular diseases are among the most challenging immune-mediated kidney disorders in childhood. Conventional corticosteroids and classical immunosuppressants remain first-line therapies, yet high relapse rates, steroid dependence, significant adverse events, and treatment resistance are common. Over the past decade, biologic agents—including belimumab, anti-CD20 monoclonal antibodies, and complement inhibitors—have shown promising efficacy in refractory or relapsing cases. However, robust pediatric data on efficacy, safety, long-term outcomes, and optimal patient selection are still scarce. Well-designed multicenter studies and clinical evidence are urgently needed to translate these novel agents into evidence-based care for children with kidney diseases.

Goal

This Research Topic aims to assemble findings on immunobiological therapies for pediatric glomerular diseases, establishing an evidence base for their clinical application. By pooling original investigations, clinical trials, case series, and systematic reviews, we seek to improve treatment strategies, identify predictive biomarkers of response, and ultimately improve renal survival and quality of life for affected children.

Scope and information for Authors

We welcome submissions that address, but are not limited to, the following themes:

• Efficacy and safety of biologics in childhood nephrotic syndrome
• Novel immunotherapeutic strategies for pediatric lupus nephritis, IgA nephritis and IgA vasculitis: clinical trials and real-world data
• Biomarkers predicting response to biologic or targeted therapy
• Individualized management of refractory cases: illustrative case series
• Telemedicine approaches for follow-up and adherence monitoring in pediatric renal diseases

Article types include Original Research, Case Series, Clinical Trials, Systematic Reviews/Meta-analyses, and Brief Research Reports.

Keywords: Biologics, glomerulonephritis, nephrotic syndrome, children, immunotherapy

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy and Practice Reviews
• Policy Brief
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Biologics, nephrotic syndrome, children, immunotherapy, glomerulonephritis

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.