Fossil energy is the cornerstone of the chemical industry. However, fossil energy is non-renewable and chemical refining based on fossil resources is a process with high carbon emissions and high pollution. In the background of carbon neutrality, it is necessary to use a kind of sustainable and green way to produce fuels and chemicals. Biomass is a renewable and clean resource. Through biological manufacturing technology, biomass can be transformed into various fuels and chemicals with fewer carbon emissions and less pollution. The core of biological manufacturing technology is to build robust microbial cell factories. In recent years, with the rapid development of synthetic biology, more and more tools and strategies have been established to redesign the functional parts, gene circuits, and systems in microorganisms, to optimize the microbial metabolic network and make it more efficiently produce useful fuel and chemicals.
This Research Topic is intended to collect Original Research articles, Methods articles, Reviews, Mini-reviews, Perspectives, and Opinion articles. These articles will reflect the recent advances in the design and construction of microbial cell factories for the production of fuels and chemicals. New synthetic biology tools, new findings, new theories, new methods, new metabolic engineering strategies, new challenges, and future perspectives for the sustainable production of fuels and chemicals by design and construction of microbial cell factories will be particularly focused on in this Research Topic. Furthermore, utilization of one-carbon substrates in microbial cell factories will also be welcome in this Research Topic.
The following topic areas are to be included, but not limited to, in this Research Topic are:
• Development of synthetic biology tools for microbial cell factories;
• Design and construction approaches including modular pathway engineering, cofactor engineering, promoter engineering, genome engineering, subcellular compartmentalization engineering, laboratory adaptive evolution, multi-omics analysis strategies, high-throughput screening, directed enzyme modification, metabolic network model reconstruction for biosynthetic pathway optimization, and dynamic regulation for robust cell factories;
• One-carbon substrates including CO2, methanol, formic acid used by cell factories for the production of fuels and chemicals.
Fossil energy is the cornerstone of the chemical industry. However, fossil energy is non-renewable and chemical refining based on fossil resources is a process with high carbon emissions and high pollution. In the background of carbon neutrality, it is necessary to use a kind of sustainable and green way to produce fuels and chemicals. Biomass is a renewable and clean resource. Through biological manufacturing technology, biomass can be transformed into various fuels and chemicals with fewer carbon emissions and less pollution. The core of biological manufacturing technology is to build robust microbial cell factories. In recent years, with the rapid development of synthetic biology, more and more tools and strategies have been established to redesign the functional parts, gene circuits, and systems in microorganisms, to optimize the microbial metabolic network and make it more efficiently produce useful fuel and chemicals.
This Research Topic is intended to collect Original Research articles, Methods articles, Reviews, Mini-reviews, Perspectives, and Opinion articles. These articles will reflect the recent advances in the design and construction of microbial cell factories for the production of fuels and chemicals. New synthetic biology tools, new findings, new theories, new methods, new metabolic engineering strategies, new challenges, and future perspectives for the sustainable production of fuels and chemicals by design and construction of microbial cell factories will be particularly focused on in this Research Topic. Furthermore, utilization of one-carbon substrates in microbial cell factories will also be welcome in this Research Topic.
The following topic areas are to be included, but not limited to, in this Research Topic are:
• Development of synthetic biology tools for microbial cell factories;
• Design and construction approaches including modular pathway engineering, cofactor engineering, promoter engineering, genome engineering, subcellular compartmentalization engineering, laboratory adaptive evolution, multi-omics analysis strategies, high-throughput screening, directed enzyme modification, metabolic network model reconstruction for biosynthetic pathway optimization, and dynamic regulation for robust cell factories;
• One-carbon substrates including CO2, methanol, formic acid used by cell factories for the production of fuels and chemicals.