Intraoperative radiotherapy (IORT) – a New Frontier for Personalized Medicine as Adjuvant Treatment and Treatment of Locally Recurrent Advanced Malignancy

The use of intraoperative radiation therapy has evolved in time from treatment that required significant shielding and set up costs to a more accessible tool to aid in treatment of cancer. In this series we will present the radiobiology and physics of how intraoperative radiotherapy provides therapeutic advantage in providing a large dose to a target while minimizing toxicity to normal surrounding tissues. We will also provide a frame work for how IORT has been used in various malignancies from head and neck cancer, breast cancer, pelvic cancers and for palliation.