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Advances in Novel Pharmacotherapeutics and Drug Discovery: Computational, Experimental, Translational, and Clinical Models.

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Editorial09 August 2024
Editorial: Advances in novel pharmacotherapeutics and drug discovery: computational, experimental, translational, and clinical models

The first article on this topic (https://doi.org/10.3389/fphar. 2023 We hope that the reader will find this research topic a useful reference for the state of the art 70 in the emerging field of pharmacotherapeutics and drug discovery through computational, 71 experimental, translational, and clinical models.CS. All the editors worked collaboratively to decide which papers were accepted or rejected, and each 79 manuscript was subject to review by the panel of editors as well as peer reviewers. This editorial 80 introduction was led by CS. 81

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ORIGINAL RESEARCH
23 January 2024
The in vivo study on antioxidant activity of wendan decoction in treating hyperlipidemia: a pharmacokinetic-pharmacodynamic (PK-PD) model
Nan Xu, 7 more and Haiyan Shi

3,661 views

15 citations

ORIGINAL RESEARCH
3 January 2024
Fraisinib: a calixpyrrole derivative reducing A549 cell-derived NSCLC tumor in vivo acts as a ligand of the glycine-tRNA synthase, a new molecular target in oncology
Iméne Ben Toumia, 23 more and Camillo Rosano

4,540 views

7 citations

ORIGINAL RESEARCH
22 November 2023
Utilizing liposomal encapsulation approach to address nephrotoxic challenges of colistimethate sodium through a preclinical study
Raktham Mektrirat, 8 more and Wasan Katip

3,509 views

9 citations

ORIGINAL RESEARCH
11 January 2024
Mechanistic insights into the ameliorative effects of hypoxia-induced myocardial injury by Corydalis yanhusuo total alkaloids: based on network pharmacology and experiment verification
Jiaying Qi, 7 more and Li Chu

3,025 views

6 citations

Current state of molecular and metabolic strategies for the improvement of L-asparaginase expression in heterologous systems
Heterologous expression of L-asparaginase (L-ASNase) has become an important area of research due to its clinical and food industry applications. This review provides a comprehensive overview of the molecular and metabolic strategies that can be used to optimize the expression of L-ASNase in heterologous systems. This article describes various approaches that have been employed to increase enzyme production, including the use of molecular tools, strain engineering, and in silico optimization. The review article highlights the critical role that rational design plays in achieving successful heterologous expression and underscores the challenges of large-scale production of L-ASNase, such as inadequate protein folding and the metabolic burden on host cells. Improved gene expression is shown to be achievable through the optimization of codon usage, synthetic promoters, transcription and translation regulation, and host strain improvement, among others. Additionally, this review provides a deep understanding of the enzymatic properties of L-ASNase and how this knowledge has been employed to enhance its properties and production. Finally, future trends in L-ASNase production, including the integration of CRISPR and machine learning tools are discussed. This work serves as a valuable resource for researchers looking to design effective heterologous expression systems for L-ASNase production as well as for enzymes production in general.

7,376 views

18 citations