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Physiological rhythms could explain why Italian university students were more likely to fail exams early or late in the day.
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Scientists have identified the human gene SDR42E1 as essential for the absorption of vitamin D from the intestine, its subsequent metabolic processing, as well as the production of lipids and steroids. Without the functional protein, the survival of cells dropped by 53%. This discovery has at least two potential applications in precision medicine. First, the experiments showed that the gene can be blocked to selectively kill cancer cells. Second, boosting SDR42E1’s expression could help treat many other diseases, for example, autoimmune and metabolic disorders, against which vitamin D and its related forms are thought to protect.
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Differences in cut-marks left behind by butchery can’t be explained by different resources, tools, or skill levels, indicating cultural practices might be responsible.
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Guest editorial by Rachael Frost, a senior lecturer at Liverpool John Moores University and author of a new Frontiers in Pharmacology article.
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