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Published on 18 Jul 2025

Gene essential for vitamin D absorption could help unlock treatments for cancer and autoimmune diseases

Scientists have identified the human gene SDR42E1 as essential for the absorption of vitamin D from the intestine, its subsequent metabolic processing, as well as the production of lipids and steroids. Without the functional protein, the survival of cells dropped by 53%. This discovery has at least two potential applications in precision medicine. First, the experiments showed that the gene can be blocked to selectively kill cancer cells. Second, boosting SDR42E1’s expression could help treat many other diseases, for example, autoimmune and metabolic disorders, against which vitamin D and its related forms are thought to protect.

Health

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Health

Published on 25 Jul 2025

Persistently, intensely grieving relations are nearly twice as likely to die within 10 years after losing a loved one

Researchers followed 1,735 people in Denmark over 10 years after their loss of loved one. 6% participants showed unabatingly high levels of grief symptoms, and these had a 88% higher hazard rate of dying from any cause over the time period than those with persistently low symptoms. The first group were likewise more likely to use healthcare services, with 186% higher odds of receiving talk therapy or other mental health services, and between 160% and 463% higher odds of being prescribed psychotropic medication. This is the first study on the long-term mortality rate and the use of healthcare in a large-scale cohort of bereaved persons. The results suggest that patients at risk for long-term ‘high grief’ may be identified in advance, and need additional support from the healthcare system.

Health

Published on 18 Jul 2025

Gene essential for vitamin D absorption could help unlock treatments for cancer and autoimmune diseases

Scientists have identified the human gene SDR42E1 as essential for the absorption of vitamin D from the intestine, its subsequent metabolic processing, as well as the production of lipids and steroids. Without the functional protein, the survival of cells dropped by 53%. This discovery has at least two potential applications in precision medicine. First, the experiments showed that the gene can be blocked to selectively kill cancer cells. Second, boosting SDR42E1’s expression could help treat many other diseases, for example, autoimmune and metabolic disorders, against which vitamin D and its related forms are thought to protect.

Health

Published on 11 Jul 2025

‘Molecular shield’ placed in the nose may soon treat common hay fever trigger

Researchers here developed a monoclonal antibody specific against mugwort pollen – an important allergen causing hay fever – in mice, which is highly effective in blocking symptoms of IgE immunoglobin-mediated allergy against this pollen. The monoclonal antibodies can be delivered inside the nose, rather than intravenously, acting almost like a ‘molecular shield’. The study is a proof-of-principle, which can be extended to other pollen species.

Neuroscience

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Environment

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Environment

Published on 05 Jun 2025

Survival of the greenest: why world’s oldest organizations are surpassing young upstarts in environmental sustainability

In a new article published in Frontiers in Organizational Psychology, Daria Haner, Dr Yilei Wang, Dr Deniz Ones, Dr Stephan Dilchert, Dr Yagizhan Yazar, and Karn Kaura unveil surprising new findings: the world’s most sustainable businesses are the world’s most long-lived businesses, too. In this guest editorial, they explain their results, discuss the potential underlying reasons for their findings, and underline the importance of sustainability to the future of business.

Space sciences and astronomy

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Space sciences and astronomy

Published on 03 Feb 2025

Can ocean-floor mining oversights help us regulate space debris and mining on the Moon?

Space belongs to no-one, yet many nations and private entities now plan to lay their claim on its resources. In a recent Frontiers in Space Technologies article, Nishith Mishra, Martina Elia Vitoloni and Dr Joseph Pelton shared their thoughts about how plans to exploit the ocean floors could impact the way resources from space are used and managed.