For this Research Topic, the pathogeneses connected to Urinary Tract Infections (UTI) have been investigated from different points of view. Duran Ramirez et al. focused on catheter-associated urinary tract infections. They presented high-throughput detection of urease activity with a semi-quantitative assay for testing potent (P. mirabilis) or weak (S. aureus) urease producers. Ballén et al. compared clinical isolates of Klebsiella pneumoniae strains for antibiotic resistance patterns and virulence factors. They reported that the isolates from urine with strong biofilm-forming abilities were more resistant to the antibiotics than those from the respiratory tract or blood. The authors concluded that the acquisition of mobile genetic elements could promote not only the spread of antimicrobial resistance genes but also virulence genes that evolve into virulent pathotypes of K. pneumoniae. Wu et al. presented the molecular mechanisms of bladder tissue injury caused by an overreaction of the immune response, which was induced by uropathogenic E. coli. They proposed the up-regulation of the alpha-mannose receptor by C5a/C5aR1, which facilitates UPEC adhesion via FimH lectin on type 1 fimbriae. Gmiter and Kaca reviewed the fate of P. mirabilis strains on solid surfaces, focusing on adhesion, biofilm formation, and the swarming phenomenon.
We thank all the authors contributing to this Research Topic despite the coronavirus pandemic. We hope that the presented studies will encourage future discoveries about the pathogenesis of UTIs.
Statements
Author contributions
NN: Conceptualization, Supervision, Writing-review and editing, WK: Conceptualization, Supervision, Writing-original draft preparation, Project administration. All authors contributed to the article and approved the submitted version.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Summary
Keywords
urinary tract infection (UTI), pathogeneses, ureolytic activity, biofilm, tissue injury
Citation
Naga N and Kaca W (2023) Editorial: Urinary tract infections: molecular mechanisms of pathogenesis. Front. Cell. Infect. Microbiol. 13:1191478. doi: 10.3389/fcimb.2023.1191478
Received
22 March 2023
Accepted
29 March 2023
Published
12 April 2023
Volume
13 - 2023
Edited and reviewed by
Kenneth Fields, University of Kentucky, United States
Updates
Copyright
© 2023 Naga and Kaca.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Naofumi Naga, nnaga@sic.shibaura-it.ac.jp
This article was submitted to Molecular Bacterial Pathogenesis, a section of the journal Frontiers in Cellular and Infection Microbiology
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.