Corrigendum: PTEN: A Thrifty Gene That Causes Disease in Times of Plenty?
Ajit Venniyoor- Department of Medical Oncology, National Oncology Centre, The Royal Hospital, Muscat, Oman
A Corrigendum on
PTEN: A Thrifty Gene That Causes Disease in Times of Plenty?
by Venniyoor, A. (2020). Front. Nutr. 7:81. doi: 10.3389/fnut.2020.00081
In the original article, there was a mistake in **Figure 1** as published.
**The caption in Box 6 (from top, right branch) reads “INCREASED THERMOGENESIS”**.
The corrected **Figure 1** appears below.
Figure 1. Deficiency of nutrients in utero, specifically proteins and choline lead to upregulation of DNMT3a and possibly 1, resulting in promoter methylation and suppression of PTEN, to varying degrees. This adapts the offspring to a nutritionally constrained post natal environment with efficient fat storage and reduced thermogenesis. If the birth environment continues to lack nutrition, the organism is well-adapted for survival, but in an obesogenic environment, would result in obesity, metabolic disorders, and cancer.
The caption should read “DECREASED THERMOGENESIS”.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Keywords: PTEN (phosphatase and tensin homolog deleted on chromosome 10), thrifty gene hypothesis, insulin resistance, carcinogenesis, polycystic ovarian disease (PCOD), diabetes mellitus, NAFLD
Citation: Venniyoor A (2020) Corrigendum: PTEN: A Thrifty Gene That Causes Disease in Times of Plenty? Front. Nutr. 7:573536. doi: 10.3389/fnut.2020.573536
Received: 17 June 2020; Accepted: 19 October 2020;
Published: 17 November 2020.
Edited and reviewed by: Maurizio Muscaritoli, Sapienza University of Rome, Italy
Copyright © 2020 Venniyoor. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Ajit Venniyoor, avenniyoor@gmail.com