%A Grimaldi,Marina %A Boulahtouf,Abdelhay %A Prévostel,Corinne %A Thierry,Alain %A Balaguer,Patrick %A Blache,Philippe %D 2018 %J Frontiers in Pharmacology %C %F %G English %K Cell models,Wnt/β-Catenin pathway,inhibitors,High-Throughput Screening,colorectal cancer %Q %R 10.3389/fphar.2018.01160 %W %L %M %P %7 %8 2018-October-11 %9 Research Snapshot %# %! Method for finding Wnt inhibitors %* %< %T A Cell Model Suitable for a High-Throughput Screening of Inhibitors of the Wnt/β-Catenin Pathway %U https://www.frontiersin.org/articles/10.3389/fphar.2018.01160 %V 9 %0 JOURNAL ARTICLE %@ 1663-9812 %X A constitutive activation of the Wnt/β-catenin pathway is an initiating event in colon carcinogenesis. We developed colon cancer cells models that highlight the non-selectivity of previously described inhibitors of the Wnt pathway and we propose our model as a suitable screening system for inhibitors of the pathway.