In the original article, there was a mistake in Figure 3D as published. During the histological evaluation, the histological images were photographed by microscope in different fields of each animal and named as the number of animal and groups, which were placed under the same folder of group name. Because of our unpremeditated mistake, the last photo of microscopic field of the animal in group C (emodin, 20 mg/kg) was wrongly named as group D (emodin, 40 mg/kg) and then saved in the group D folder. This unpremeditated mistake caused a coincidental error of picking out the typical photo of each group in preparing Figure 3, that a wrongly named group C photo was picked out from group D folder and was wrongly regarded as group D photo. This does not impact on the interpretation of the data results. In groups C and D, 20 or 40 mg/kg of emodin were administered respectively to normal rats, which showed no significantly histological lesions in either group C or group D. All the animals in the two groups showed accordant results of no histologic lesions and the serum hepatic biochemistry indices did not reveal alterations. These results are consistent with the literatures and expectable as the dosages of emodin were significantly lower than the toxic dosage of this compound in normal rats. Thus, this corrigendum affects neither the interpretation of the data nor conclusions of this work. The corrected Figure 3 appears below.
FIGURE 3
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Summary
Keywords
emodin, lipopolysaccharide, hepatotoxicity, therapeutic dosages, proinflammatory mediators, idiosyncratic drug-induced liver injury
Citation
Tu C, Gao D, Li X-F, Li C-Y, Li R-S, Zhao Y-L, Li N, Jia G-L-C, Pang J-Y, Cui H-R, Ma Z-J, Xiao X-H and Wang J-B (2021) Corrigendum: Inflammatory Stress Potentiates Emodin-Induced Liver Injury in Rats. Front. Pharmacol. 11:597772. doi: 10.3389/fphar.2020.597772
Received
22 August 2020
Accepted
30 October 2020
Published
25 January 2021
Volume
11 - 2020
Edited by
Michael Heinrich, China Medical University, Taiwan
Updates
Copyright
© 2021 Wang, Tu, Gao, Li, LI, Li, Zhao, Li, Liuchang, Pang, Cui, Ma and Xiao.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Xiao-He Xiao, pharmacy302xxh@126.com; Jia-Bo Wang, pharm_sci@126.com
This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology
†These authors have contributed equally to this work
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