CORRECTION article

Front. Pharmacol., 16 June 2025

Sec. Ethnopharmacology

Volume 16 - 2025 | https://doi.org/10.3389/fphar.2025.1636607

Correction: Polygoni Multiflori Radix Praeparata polysaccharides enhance gut health and mitigate ischemic stroke by regulating SCFA and amino acid metabolism in gut microbiota

  • 1. School of Pharmacy and School of Biological and Food Engineering, Changzhou University, Changzhou, China

  • 2. School of Pharmacy, Modern Industrial College of Traditional Chinese Medicine and Health, Lishui University, Lishui, China

  • 3. Center of Molecular Metabolism, Nanjing University of Science and Technology, Nanjing, China

  • 4. The Second People’s Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, China

  • 5. Changzhou Medical Center, Nanjing Medical University, Changzhou, China

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There was an error in Figure 3 as published. The authors inadvertently substituted a 40× image from the Sham group with a 40× image from the HCK group in Figure 3A. Because intestinal histology differs markedly between groups (fold architecture, mucosal arrangement, etc.), the mismatch was readily apparent. The incorrect original 40× image of the Sham group was an enlarged image of the HCK 20× image. The authors have now retrieved the correct 40× micrographs for both the Sham and HCK groups from the raw data and have reconstructed Figure 3A accordingly. The corrected Figure 3 appears below.

FIGURE 3

Histological analysis showing intestinal tissue samples across different conditions: Sham, MCAO, LM, HM, and HCK. Panel A illustrates hematoxylin and eosin staining at two magnifications (twenty times and forty times). Panel B shows immunohistochemical staining for ZO-1, Occludin, and Claudin 1. Bar graphs depict the positive rate percentages for each protein, indicating changes in expression across conditions.

PMP has an ameliorating effect on colon injury in MCAO rats. (A) Representative micrographs of H&E staining in the colon. (B) Representative immunohistochemical images and statistical maps of tight junction protein. n = 4. *p < 0.05, **p < 0.01 and ***p < 0.001, MCAO group vs. Sham group; #p < 0.05, ##p < 0.01 and ###p < 0.001, dosing group vs. MCAO group.

There was an error in Figure 4 as published. Previously, in Figure 4B the scale bar was positioned outside the image. This has now been adjusted to ensure a consistent style. The corrected Figure 4 appears below.

FIGURE 4

Histological images and bar graphs displaying TNF-α, IL-1β, IL-6, and IL-13RA2 positive rates in Sham, MCAO, LM, HM, and HCK groups. Bar graphs indicate significant differences in expression levels among these groups, with symbols denoting statistical significance.

PMP ameliorates MCAO-induced inflammatory response in rats' colon. Representative immunohistochemical images and statistical maps of inflammatory factors. n = 4. *p < 0.05, **p < 0.01 and ***p < 0.001, MCAO group vs. Sham group; #p < 0.05, ##p < 0.01 and ###p < 0.001, dosing group vs. MCAO group.

The original version of this article has been updated.

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Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Summary

Keywords

polygoni multiflori radix praeparata, polysaccharides, acute ischemic stroke, gut microbiota, metabolomics

Citation

Ruan L, Wang Z, Zheng M, Zheng Q, Qing Q, Lin H, Tao Y, Wang L, Wang J and Ge W (2025) Correction: Polygoni Multiflori Radix Praeparata polysaccharides enhance gut health and mitigate ischemic stroke by regulating SCFA and amino acid metabolism in gut microbiota. Front. Pharmacol. 16:1636607. doi: 10.3389/fphar.2025.1636607

Received

28 May 2025

Accepted

02 June 2025

Published

16 June 2025

Volume

16 - 2025

Edited and reviewed by

Michael Heinrich, University College London, United Kingdom

Updates

Copyright

*Correspondence: Junsong Wang, ; Wenhao Ge,

†These authors have contributed equally to this work and share first authorship

Disclaimer

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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