%A Preuss,Ulrich W. %A Huestis,Marilyn A. %A Schneider,Miriam %A Hermann,Derik %A Lutz,Beat %A Hasan,Alkomiet %A Kambeitz,Joseph %A Wong,Jessica W. M. %A Hoch,Eva %D 2021 %J Frontiers in Psychiatry %C %F %G English %K Cannabis,Cannabinoids,THC; automobile driving,Impaired driving,Driving safety,Driving skills,driving ability 3 %Q %R 10.3389/fpsyt.2021.643315 %W %L %M %P %7 %8 2021-May-28 %9 Systematic Review %# %! Cannabis Car Crash Risk %* %< %T Cannabis Use and Car Crashes: A Review %U https://www.frontiersin.org/articles/10.3389/fpsyt.2021.643315 %V 12 %0 JOURNAL ARTICLE %@ 1664-0640 %X In this review, state-of-the-art evidence on the relationship between cannabis use, traffic crash risks, and driving safety were analyzed. Systematic reviews, meta-analyses, and other relevant papers published within the last decade were systematically searched and synthesized. Findings show that meta-analyses and culpability studies consistently indicate a slightly but significantly increased risk of crashes after acute cannabis use. These risks vary across included study type, crash severity, and method of substance application and measurement. Some studies show a significant correlation between high THC blood concentrations and car crash risk. Most studies do not support this relationship at lower THC concentrations. However, no scientifically supported clear cut-off concentration can be derived from these results. Further research is needed to determine dose-response effects on driving skills combined with measures of neuropsychological functioning related to driving skills and crash risk.