%A Shi,Lin %A Zheng,Leilei %A Jin,Danni %A Lin,Zheng %A Zhang,Qiaoling %A Zhang,Mao %D 2022 %J Frontiers in Public Health %C %F %G English %K Driving fatigue,Traffic Safety,Pupillary light reflex (PLR),Heart rate variability,Automated pupillometry %Q %R 10.3389/fpubh.2022.828428 %W %L %M %P %7 %8 2022-February-21 %9 Original Research %# %! Driving fatigue detection using pupillometry %* %< %T Assessment of Combination of Automated Pupillometry and Heart Rate Variability to Detect Driving Fatigue %U https://www.frontiersin.org/articles/10.3389/fpubh.2022.828428 %V 10 %0 JOURNAL ARTICLE %@ 2296-2565 %X ObjectivesApproximately 20~30% of all traffic accidents are caused by fatigue driving. However, limited practicability remains a barrier for the real application of available techniques to detect driving fatigue. Use of pupillary light reflex (PLR) may be potentially effective for driving fatigue detection.MethodsA 90 min monotonous simulated driving task was utilized to induce driving fatigue. During the task, PLR measurements were performed at baseline and at an interval of 30 min. Subjective rating scales, heart rate variability (HRV) were monitored simultaneously.ResultsThirty-two healthy volunteers in China participated in our study. Based on the results of subjective evaluation and behavioral performances, driving fatigue was verified to be successfully induced by a simulated driving task. Significant variations of PLR and HRV parameters were observed, which also showed significant relevance with the change in Karolinska Sleepiness Scale at several timepoints (|r| = 0.55 ~ 0.72, P < 0.001). Furthermore, PLR variations had excellent ability to detect driving fatigue with high sensitivity and specificity, of which maximum constriction velocity variations achieved a sensitivity of 85.00% and specificity of 72.34% for driving fatigue detection, vs. 82.50 and 78.72% with a combination of HRV variations, a nonsignificant difference (AUC = 0.835, 0.872, P > 0.05).ConclusionsPupillary light reflex variation may be a potential indicator in the detection of driving fatigue, achieving a comparative performance compared with the combination with heart rate variability. Further work may be involved in developing a commercialized driving fatigue detection system based on pupillary parameters.